Project Grant R21AG088610

Award Date 9/1/24
Completion Date 8/31/27
Dollars Obligated $626K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Illinois, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $462,923 to Albany Medical College to develop new mouse models of andropause (age-related decline in male sex hormones) for Alzheimer's disease and related dementia (ADRD) research. The primary goals are to: Determine the natural time course of endocrine aging in wild-type mice and mouse models of ADRD (Aim 1). Model endocrine aging in male mice via gonadectomy and gradual androgen...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $298,883 to Iaterion, Inc. to develop a safer menopausal hormone therapy (MHT) formula that can be used long-term to treat protracted menopausal symptoms and prevent chronic diseases like osteoporosis, diabetes, obesity, and metabolic syndrome. The project aims to create an estradiol/reprogramming ligand combination that can potentially replace the progestin component of current MHT...
The National Institute on Aging (NIA) awarded a $391,101 Project Grant under the Aging Research program (CFDA 93.866) to The Ohio State University to develop a novel nonsteroidal and nonhormonal agent that reverses menopause-related loss of genital epithelial integrity and function. The research aims to define the mechanism of action, optimize delivery, and establish the long-term safety profile of an EFNA3-mimetic agonist peptide (EFNA3-MAP) administered intravaginally to restore genital...
The National Science Foundation (NSF) awarded a $333,589.00 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of Utah. The grant, awarded on September 1, 2023, supports a collaborative research project aimed at (1) advancing the understanding of ovarian aging and (2) optimizing technologies designed to delay the onset of menopause. The project leverages mathematical and statistical theories of randomness to explain longstanding mysteries in...
This $576,926 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a research project to characterize the cellular and molecular changes in the human anterior hippocampus across the menopausal transition. The project, led by Fordham University, will utilize single-nucleus multiome analysis and micro-C techniques to define shifts in gene expression, chromatin states, and 3D genome organization in...
The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant (CFDA 93.866 - Aging Research) to the University of Pittsburgh to conduct a 5-year longitudinal investigation of the relationship between menopause and brain health. The project, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," aims to elucidate the brain and cognitive changes that occur during the perimenopause stage and the factors that contribute to these changes. Key activities...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $419,056 to Texas A&M AgriLife Research to develop nanoparticle-based therapies to improve mitochondrial function and treat metabolic disease in post-menopausal women. The research aims to determine if two distinct nanoparticles - molybdenum disulfide (MoS2) nanoflowers and mitochondria-targeted estradiol (Mito-E2) - can enhance mitochondrial function and reduce oxidative stress in...
This $643,049 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a physiomimetic (tissue-engineered) model of the endometrioma lesion microenvironment. The project's objective is to investigate the processes responsible for the initiation and invasion of endometriosis lesions, which could inform the design of effective therapeutic strategies....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $564,530 to Emory University to investigate the associative role of the Alzheimer's disease (AD) risk gene APOE4 and the menopause-related hormone follicle-stimulating hormone (FSH) in the initiation and progression of AD, particularly in women. The project aims to explore how APOE4 facilitates AD pathology related to FSH-induced mechanisms, examine how APOE4 mediates tau propagation and...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...

This $625,898 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop spatially-informed, cell-specific metabolic models of the ovary to identify novel biomarkers associated with the onset and duration of the menopause transition. The key products and services to be delivered include:

  1. Generation of spatially-informed, cell-specific, multicellular genome-scale metabolic models (GMMs) of the ovary using single-cell and spatial transcriptomics data from prepubertal to aged mice.

  2. Identification of ovarian-synthesized metabolites that can be measured in circulation and are significantly associated with reproductive potential and its rate of decline.

The goal is to create a platform for early prediction of menopause transition onset and duration, in order to reduce the risk of menopause-related diseases. The 3-year project will be conducted by the University of Illinois and is expected to be completed by August 31, 2027.

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