Project Grant R21AG088600
- This $578,329 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to leverage invasive brain recordings and immersive virtual reality to characterize the mechanisms underlying freezing of gait in Parkinson's disease. The primary objectives are to determine how gait-related neural oscillations in the globus pallidus internus and...
- This federal Project Grant award of $476,643.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to study the neurophysiological basis of impaired gait in mouse models of Parkinson's disease. The key objectives are to examine how the dorsolateral striatum and substantia nigra pars reticulata, which are part of the basal ganglia, encode gait...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $142,995 to the Regents of the University of Minnesota to investigate the neural mechanisms underlying impaired postural control in people with Parkinson's disease. The research will use transcranial magnetic stimulation (TMS) and electrical vestibular stimulation (EVS) to characterize the...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $665,118 supports a study to examine the neural mechanisms underlying the benefits of aerobic exercise for advanced Parkinson's disease (PD) patients with deep brain stimulation (DBS) implants. The research will enroll 51 advanced PD patients with DBS to assess the impacts of voluntary and forced aerobic exercise on motor, cognitive, and dual-task performance. Neural activity...
- This federal Project Grant award of $140,690 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate the relationship between gamma oscillations in the motor network and dyskinesia (excessive movement) in Parkinson's disease patients. The goals are to use chronically implanted neurostimulators and wearable sensors...
- This $112,158 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in basal ganglia neural activity associated with depression in Parkinson's disease (PD) patients. The research aims to determine the specific brain regions and networks involved, as well as evaluate the effects of deep brain stimulation (DBS)...
- This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $771,627 provides funding to The Washington University to develop and evaluate a metacognitive strategy intervention for addressing cognitive decline in individuals with Parkinson's disease (PD). The long-term goal of the research is to reduce disability, improve quality of life, and delay dementia onset among people with PD by enabling them to cope with cognitive decline and perform...
- This $423,147 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will fund research to understand the effects of mild cognitive impairment (MCI) and Alzheimer's disease (AD) on gait function and locomotor flexibility. The project will compare split-belt treadmill adaptation, gait performance, and cognitive function between healthy older adults, those with MCI, and those with AD. Longitudinal assessments will track disease...
- This federal Project Grant award, funded by the National Science Foundation (NSF) Engineering program (CFDA 47.041), will support research to investigate how changes in brain function due to Parkinson's disease (PD) impact movement dysfunction. The $199,401 award to Florida Polytechnic University, a state-controlled institution of higher learning, will employ modeling, simulation, and robotic-based movement studies to gain insights into the neural mechanisms underlying both inhibitory and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $405,045.00 to the University of Florida to study the neural mechanisms underlying locomotor adaptation deficits and freezing of gait in Parkinson's disease (PD) patients. The project aims to understand how abnormal neural oscillations in the globus pallidus internus (GPI) disrupt the regulation of human walking in PD. The research will utilize a split-belt treadmill paradigm and record local field potentials from the GPI of 60 PD patients implanted with deep brain stimulation devices. The findings are expected to provide new insights into the neurophysiology of locomotor adaptation and strategies to alleviate gait impairments in PD. The project will be conducted over 2 years from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $405.0k | 7/30/25 |