Project Grant R21AG087875
Award Date
9/15/24
Completion Date
6/30/26
Dollars Obligated
$459K
Federal Agency
National Institute on Aging
Awardee
Yale Univ (FL6GV84CKN57)
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Hamden, CT 06511, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Emory University's research into the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The $528,876 award, effective June 1, 2025, will fund the development of new analytic tools to integrate genomic data across multiple tissues and improve the identification of genetic risk factors and underlying molecular mechanisms for...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $461,146 to Yale University to conduct research on the dysregulation of cortical astrocytes in models of Alzheimer's disease. The research aims to: Assess the early loss of state-dependent spatiotemporal dynamics of astrocytic signaling as an initial consequence of Alzheimer's pathology. Investigate the progressive loss of coupling between noradrenergic signaling and astrocyte activity due...
This Project Grant award of $762,636 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports the development of interpretable machine learning methods for analyzing Alzheimer's disease genetics. The research aims to improve understanding of the complex genetic basis of Alzheimer's disease and identify novel therapeutic targets. Key objectives include applying advanced machine learning techniques to large-scale genetic and multi-omics datasets, while...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $416,480 to the University of Washington to map the landscape of the aged human brain and develop neurodegenerative disease models. The award will fund a two-phase research project that aims to: 1) identify molecular drivers of brain aging by applying explainable artificial intelligence (XAI) methods to human brain datasets, and 2) manipulate these aging drivers in human induced pluripotent stem...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $385,612 aims to integrate experimental and computational models to study prefrontal microcircuit changes during healthy aging and Alzheimer's disease progression. The research team at the University of Wyoming will use in vivo calcium imaging, computational simulation modeling, and neural decoding to directly visualize and predict microcircuit changes in the prefrontal cortex. A sub-award of an...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,238 to The University of Texas Health Science Center at San Antonio to study the role of senescent cells in Alzheimer's disease and related dementias (ADRD). The primary goals are to: Identify molecular markers and changes in the microenvironment of senescent neurons compared to healthy neurons, with a focus on their contribution to neuronal death in brain aging and ADRD (R21 phase). Use...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $817,357 to the J. David Gladstone Institutes to develop advanced machine learning approaches for comprehensive behavioral and brain signal analysis in humanized Alzheimer's disease mouse models. The key products and services to be delivered include: Validating a machine learning platform called Variational Animal Motion Embedding (VAME) for high-resolution...
The National Institutes of Health's National Institute on Aging awarded $256,331.40 under the Aging Research program (CFDA 93.866) to The Trustees of the University of Pennsylvania from February to October 2021. The project aims to develop novel machine learning algorithms and biomedical software to more accurately quantify brain aging and predict the onset of neurodegenerative diseases such as Alzheimer's. Specifically, the funding will support refining predictive models of the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $802,034 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to develop a Multimodal, Multiscale and Multistage Systems Biology (M3SB) infrastructure for precision medicine in Alzheimer's disease and longevity. The key products and services to be delivered include: Multi-modal analyses of genetics, multi-omics data, cross-species protein interactome...
The National Institute on Aging (NIA) awarded a $619,681 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop innovative tools for studying the complex genetic interactions underlying Alzheimer's disease (AD) pathogenesis. The project, titled "Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models", will create a toolkit combining gene-editing...