This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $239,122 to Yale University to leverage computational and experimental approaches to study the impact of aging processes and Alzheimer's disease (AD) risk variants on chromatin accessibility and gene expression in human neural and glial cells. The 2-year project aims to: 1) develop a cell-type specific regulatory network model for normal brain aging and AD brain aging, and 2) generate...
This Project Grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $5,006,006 to Yale University to support multimodal imaging research aimed at better understanding Alzheimer's disease pathogenesis and treatment response. Specifically, the award will fund research leveraging positron emission tomography, wide-field calcium imaging, and functional magnetic resonance imaging to map changes in excitatory and inhibitory...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brown University totals $771,518.10 and runs from September 1, 2024 to May 31, 2029. The project aims to elucidate the role of the protein CHI3L1/YKL-40 in the pathogenesis of Alzheimer's disease (AD). Specifically, the research will: 1) Investigate how CHI3L1 induces neuronal apoptosis and neurodegeneration through interactions with receptors on neurons and microglia, using human stem...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $6,226,692 to The Trustees of Columbia University in the City of New York to conduct research on the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the progression of Alzheimer's disease. The research aims to identify key early events in Alzheimer's disease pathology, particularly in the locus coeruleus and hippocampus regions of the brain, and...
This $815,215 Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) supports a comprehensive study on sex-based differences in Alzheimer's disease (AD) pathology and progression. The research aims to leverage neuroimaging techniques, plasma biomarkers, and tau PET imaging to investigate how sex and sex-based factors, such as reproductive period and APOE genotype, impact functional brain networks and the spread of tau pathology...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai provides $842,114 to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The project aims to identify and characterize senescent cells in major subtypes of AD using advanced single-cell multi-omics and spatial transcriptomics techniques. This comprehensive research initiative is...
This federal Project Grant award for $461,313, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the role of the protein CSPα in regulating synaptic autophagy and its implications for neurodegenerative diseases. The research aims to characterize synaptic vesicles, autophagosomes, and related proteins in wild-type, CSPα knockout, and CLN4 (a neurodegenerative disease) models using techniques such as electron microscopy,...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $812,030 to The Trustees of the University of Pennsylvania to develop and optimize noninvasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The research aims to explore the connections between neuroinflammation, brain glucose hypometabolism, and AD progression using advanced magnetic resonance imaging techniques like...
The National Institute on Aging (NIA) awarded a $522,500 Project Grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The grant, with an award date of September 30, 2024 and an ultimate completion date of August 31, 2026, will fund research to investigate the role of astrocytes, a type of non-neuronal glial cell, in driving age-related motor and cognitive decline in the brain. Key objectives include determining if the transcription factor...