This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $400,000.00 in funding to Baylor College of Medicine to conduct research on the cellular and molecular mechanisms that govern bladder aging. The key objectives are to: Define the role of ribosomal and translational quality control machinery in maintaining bladder homeostasis and response to urinary tract infections in young, aged, and genetically-modified mouse models. This includes using a 3D...
The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
The University of California, San Francisco (UCSF) was awarded a $474,043 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the utilization, outcomes, and complications associated with third-line treatments for refractory overactive bladder (OAB) in older and frail older adults. The study aims to better understand how factors such as age, frailty, race, socioeconomic status, and provider experience impact the use and...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $389,852 Project Grant to Dignify Therapeutics, LLC to develop novel drug formulations for treating urinary incontinence (UI) and overactive bladder (OAB) symptoms in the elderly. The grant supports a research project to create new intravesical (bladder-instilled) drug therapies that can block pain-sensing neurons and provide long-term relief of UI and OAB for elderly patients who are unresponsive to current treatments. The...
This Project Grant award, valued at $231,000.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding supports research conducted by the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of cyclic guanosine monophosphate (cGMP) signaling in intestinal aging. The primary objectives are to characterize cGMP signaling in the...
The National Institute on Aging (NIA) awarded a $558,222 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Maryland, Baltimore to investigate the roles of the CircHIPK3 circular RNA and the HuR RNA-binding protein in regulating intestinal barrier function during aging. The 5-year research project (Sep 2024 - Aug 2029) aims to elucidate how CircHIPK3 and HuR modulate mitochondrial function in the aging intestinal epithelium, and how these molecular...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
The project, titled "Improving Incontinence Support for Family Caregivers and Persons Living with Dementia," is funded by a $246,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) with a start date of September 1, 2024 and an end date of June 30, 2026. The overarching objective of this project is to better understand the unique urinary incontinence (UI) support needs, preferences, and priorities of family caregivers of persons living with...
The National Institute on Aging (NIA), through its Aging Research Federal Grant Program (CFDA 93.866), awarded a $2,495,639 project grant to the University of California, San Diego (UCSD) to develop a regenerative biomaterial therapy for treating genitourinary syndrome of menopause (GSM). The 4-year grant will fund research to determine if a novel vaginal tissue-derived extracellular matrix (VECM) hydrogel can reverse vaginal atrophy and restore healthy vaginal function in a preclinical GSM...