This Project Grant award, valued at $231,000.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding supports research conducted by the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of cyclic guanosine monophosphate (cGMP) signaling in intestinal aging. The primary objectives are to characterize cGMP signaling in the...
This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $449,625 to Trustees of Boston University to explore the role of circular RNAs in aging-related sepsis and organ damage. The research aims to determine the function and mechanisms of an aging-induced circular RNA, circ20033, in promoting pro-inflammatory activation of macrophages and lung inflammation after bacterial infections, particularly in older adults. The two-year project will...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award of $660,908 was provided by the National Institute on Aging (CFDA 93.866, Aging Research) to Brandeis University. The project aims to expand on previous research demonstrating that certain circular RNAs (circRNAs) can regulate lifespan and health span. Specifically, the research will: 1) determine the mechanisms behind circRNAs that promote aging, 2) examine the extent and requirements for circRNA translation and its relationship to aging, and 3) define the...
This National Institute on Aging (NIA) Project Grant award to Emory University, under the Aging Research program (CFDA 93.866), provides $430,375 to determine whether the microbiome metabolite valerobetaine (VB) promotes a mitochondrial aging phenotype in old mice and to test whether VB antagonizes the beneficial effects of carnitine (acetylcarnitine) on mitochondrial aging. The two-year project, running from September 2023 to September 2025, will conduct experimental studies in young and old...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a 5-year, $753,728 Project Grant (R01AG085793) to the University of Alabama at Birmingham (UAB) to investigate the role of ceramide signaling in regulating healthspan and lifespan in mouse models. The study aims to determine the association between growth hormone deficiency, altered lipid profiles, and longevity, with a focus on the implications of ceramides in aging-related processes...