Project Grant R21AG083635
Award Date
9/15/24
Completion Date
8/31/26
Dollars Obligated
$231K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Augusta, GA 30912, USA
Similar Awards
This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
The National Institute on Aging (NIA) awarded a $558,222 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Maryland, Baltimore to investigate the roles of the CircHIPK3 circular RNA and the HuR RNA-binding protein in regulating intestinal barrier function during aging. The 5-year research project (Sep 2024 - Aug 2029) aims to elucidate how CircHIPK3 and HuR modulate mitochondrial function in the aging intestinal epithelium, and how these molecular...
This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $2,496,057.49 to the University of Arizona to investigate the role of hepatic glucagon receptor signaling in healthspan and aging. The research aims to study the impact of genetic and pharmacological manipulation of glucagon receptor signaling on normal aging, obesity-accelerated aging, and the effects of calorie restriction. This work seeks to identify glucagon receptor...
The National Institute on Aging (NIA) awarded a $262,808 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Gerontological Society of America (GSA). The purpose of this 4-year GET2 (Geroscience Education and Training 2) Network award, starting on August 1, 2025, is to enhance access to a Geroscience Certificate Research Program, increase the geroscience workforce, and systematically evaluate the quality, adoption, and impact of geroscience curricula. This will be...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
The National Institute on Aging (NIA) awarded a $439,535 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Colorado from September 30, 2023 to September 29, 2025. This grant will fund research to investigate the interplay between active smooth muscle cell contractility and passive extracellular matrix mechanics in the aging bladder, with the goal of gaining insight into the development of lower urinary tract symptoms in older adults. The University...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This National Institutes of Health National Institute on Aging project grant awarded $105,176 to Augusta University Research Institute, Inc. to support research directed at understanding the potential link between aging-related decreases in bone mass and kidney function. Specifically, the award will fund investigation of how increased levels of the metabolite kynurenine may induce an aged phenotype resulting in both bone loss and kidney dysfunction through the FGF23/klotho pathway. The...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...