Project Grant R21AG085588

Award Date 9/15/24
Completion Date 5/31/26
Dollars Obligated $641K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
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This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) is funding a $109,595 project at the University of California, Davis to characterize a novel non-human primate model of Alzheimer's disease. The project aims to perform comprehensive microscopic analyses to determine the patterns of tau-based neuropathology, neuronal loss, synaptic health, and neural circuit functionality in the brains of rhesus macaques with progressive tau...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to conduct research on the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease. The research aims to identify mechanisms that drive the interaction between these two pathological hallmarks of Alzheimer's and how they contribute to cognitive decline and neurodegeneration. Key activities include using C. elegans models to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This Project Grant award, with a total funding amount of $130,302.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award, with an effective date of July 15, 2025 and an ultimate completion date of March 31, 2030, supports research at New York University (NYU) to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons and its consequences for Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The project aims to substantially expand understanding of protein dysfunctions in AD by applying state-of-the-art proteomic methods paired with proteogenomics across multiple brain regions, AD stages,...
This Project Grant award of $628,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy and whether targeting synaptic autophagy can be neuroprotective in an AD mouse model. The research will utilize primary hippocampal cell cultures and mouse models to determine which steps in the autophagic processing of synaptic proteins are disrupted by AD, and evaluate if overexpressing the...
The National Institute on Aging (NIA) awarded a $1,147,300 Project Grant (CFDA 93.866 - Aging Research) to Wayne State University for a project titled "Local Protein Synthesis in Tau Pathology Neurodegeneration". The award period runs from Sep 1, 2024 to Jun 30, 2029. The project aims to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. The researchers will...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the role of microglia, the brain's immune cells, in the development of Alzheimer's disease (AD). The University of Washington (UW) will leverage novel explainable AI techniques and human induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes that occur early in AD progression. Specifically, UW will expose microglia-neuron iPSC cultures to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,283,334.00 to the Morehouse School of Medicine (MSM) to develop and validate a progressive mouse model for Traumatic Brain Injury-related Alzheimer's Disease and Related Dementias (TBI-ADRD). The project aims to systematically screen mouse strains and TBI injury types to identify the optimal model for recapitulating key neuropathological, neurobiochemical, and neurocognitive features of human...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,895 to the University of Wisconsin - Madison to characterize a novel mouse model with pathology resembling early-stage Alzheimer's disease (AD). The key objectives are to:

  1. Determine the spatial and temporal progression of pathological changes, such as tauopathy and neurodegeneration, across different cell types in the mutant mouse brain.

  2. Identify the key cellular and molecular drivers of the tauopathy phenotype observed in this model.

By developing this novel mouse model, the researchers aim to provide a tool for elucidating the underlying mechanisms of AD tauopathy development, particularly as it relates to the role of microglia and neuroinflammation. This knowledge could inform the design of more effective interventions for AD. The award period runs from September 2024 through May 2026.

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