This $109,595 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the University of California, Davis (UC Davis) will support a comprehensive microscopic study of a novel nonhuman primate model of Alzheimer's disease. The research aims to fully characterize the regional and laminar patterns of tau-based neuropathology, neuronal loss, synaptic health, and neural circuit functionality within the entorhinal cortex, hippocampus, and neocortical regions of rhesus macaques over the 12-month timeframe following virus-mediated induction of tau pathology. The behavioral data being collected concurrently on these animals will be correlated with the detailed microscopic findings, resulting in a highly validated translational model for efficiently developing and testing Alzheimer's disease therapeutics. This award advances the National Institute on Aging's mission to support research that enhances the understanding of the aging process and age-related diseases.
Generated 3/4/25, 7:18 AM