Project Grant RF1NS138029

Award Date 9/18/24
Completion Date 8/31/27
Dollars Obligated $2.3M
Funding Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30310, USA
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This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
This federal Project Grant award, valued at $3,102,638.00 and spanning August 15, 2024 to July 31, 2027, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania. The grant aims to develop novel gyrencephalic animal models that can recapitulate the complex neuropathological and clinical features associated with traumatic brain injury (TBI)-induced Alzheimer's disease and related dementias (ADRD). The project will evaluate...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $640,895 to the University of Wisconsin-Madison to characterize a novel mouse model with Alzheimer's disease (AD) pathology resembling Braak stage I/II. The goal is to develop this mouse line into a new animal model for AD research. The project will: 1) determine the spatial and temporal progression of pathological changes across different cell types in the mutant mouse...
This $678,029 project grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), seeks to develop a Bayesian computational system to model longitudinal functional microcircuits and use it to examine microcircuit changes in a TDP-43 knockout mouse model. The project aims to 1) develop a computational system for longitudinal microcircuit modeling, and 2) understand microcircuit changes in a TDP-43 knockout mouse model. The University of Maryland, Baltimore is...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $102,948.00 to Case Western Reserve University to investigate the link between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The key objectives are to assess how acute TBI induces changes to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $3,770,822 will fund research conducted by the University of Pittsburgh to investigate the relationship between epigenetic aging and patient outcomes after severe traumatic brain injury (TBI). The study aims to determine if accelerated epigenetic aging, as measured by DNA methylation, is linked to poorer recovery and increased risk of Alzheimer's disease and related dementias in TBI patients....
This $817,357 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to develop robust machine learning (ML) and computational tools for comprehensive behavioral and brain signal analysis in humanized Alzheimer's disease (AD) mouse models. The key products/services to be delivered include: Further validation of the researchers' "Variational Animal Motion Embedding" (VAME) ML platform for high-resolution behavioral segmentation and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $462,923 to Albany Medical College to develop new mouse models of andropause (age-related decline in male sex hormones) for Alzheimer's disease and related dementia (ADRD) research. The primary goals are to: Determine the natural time course of endocrine aging in wild-type mice and mouse models of ADRD (Aim 1). Model endocrine aging in male mice via gonadectomy and gradual androgen...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,283,334.00 to the Morehouse School of Medicine (MSM) to develop and validate a progressive mouse model for Traumatic Brain Injury-related Alzheimer's Disease and Related Dementias (TBI-ADRD).

The project aims to systematically screen mouse strains and TBI injury types to identify the optimal model for recapitulating key neuropathological, neurobiochemical, and neurocognitive features of human TBI-ADRD. This "team science" approach will leverage a multi-site collaboration to improve model reproducibility. The final deliverable is an optimized, validated TBI-ADRD mouse model that can be disseminated to facilitate its use by other TBI researchers. The award period runs from September 2024 through August 2027.

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