The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $302,318 Project Grant under the Oral Diseases and Disorders Research Program (CFDA 93.121) to Rutgers, The State University. The grant will fund research to investigate the effects of skull malformations and intracranial hypertension on the glymphatic and meningeal lymphatic systems in craniosynostosis. Key aims include testing if impaired glymphatic (cerebrospinal fluid) influx and efflux impedes the clearance of...
This Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) will provide $426,829 to Virginia Polytechnic Institute & State University from September 1, 2024 to May 31, 2026 to develop a microphysiological system that models the brain-meninges-lymph node axis in both healthy conditions and Alzheimer's disease. The goal is to create a modular, all-human system that can be used to study the interactions between the brain, meninges, and lymph nodes, and the...
This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $10,847,672 to the J. David Gladstone Institutes, a non-profit biomedical research organization, to investigate the vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The research aims to elucidate the key microglial mechanisms regulating the formation of vascular CAA versus parenchymal amyloid-beta plaques, define single-cell and...
This three-year Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $4.5 million to study the effects of aging and exercise on dural lymphatic clearance in healthy and diabetic human brains under the Aging Research program (CFDA 93.866). The University of California, San Diego will use non-invasive MRI techniques to examine dural lymphatic perfusion at the meninges in healthy subjects and compare results to age- and sex-matched adults...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Southern California provides $622,401 over 5 years starting January 1, 2025 to research causal models of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict ADRD pathology from diffusion MRI data, 2) generate individualized brain morphology prediction maps as "digital...