This $4,692,540.00 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at Northwestern University to develop advanced MRI techniques to directly assess cerebral microvascular pulsatility on widely available 3T MRI systems. The research aims to further the understanding of how cerebral microvascular dysfunction may contribute to cerebral small vessel disease (CSVD) and provide a novel diagnostic technology for CSVD. The award period runs from...
The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded the University of Washington a $303,614 Project Grant (R03AG081836) to develop a computational model for accurately calculating cerebrospinal fluid (CSF) velocities and brain tissue deformation. The goal is to create novel, non-invasive biomarkers for early detection of Alzheimer's disease by measuring impairment of CSF flow and brain tissue stiffness, which are linked to the...
This federal Project Grant award of $6,578,788 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports a comprehensive study on chronic traumatic encephalopathy (CTE) and related dementias. The research aims to retain and expand an existing cohort of former football players and controls to examine the clinical presentation, biomarker profiles, and risk/resilience factors associated with CTE and Alzheimer's disease. Key activities include longitudinal clinical...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $559,820 to the University of South Carolina to conduct research on the biomechanics of the human brain during high-severity impacts. The project aims to integrate dynamic MRI and sonomicrometry techniques to measure brain deformation under both mild and injurious...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
This Project Grant award of $580,654 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will support the development of a novel interferometric diffuse optics (IDO) system to improve the measurement of cerebral blood flow in patients with delayed cerebral ischemia (DCI) following subarachnoid hemorrhage. The research aims to enhance the signal-to-noise...
This federal Project Grant award of $3,125,393, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to develop a computational multimodal approach to better understand the underlying heterogeneity of age-related white matter hyperintensities (WMH) and their association with various neurological conditions. The key products and services to be delivered under this grant include: 1) Deriving distinct, disease-specific WMH spatial patterns from neuroimaging data using...
This National Institute on Aging federal Project Grant award, under the Aging Research program (CFDA 93.866), provides $4,269,339 in funding to Trustees of Boston University's medical campus to investigate the long-term clinical and neuropathological consequences of repetitive head impacts (RHI) across the lifespan. The research aims to delineate how RHI exposure, especially early in life, can initiate structural brain changes, inflammation, neuronal/white matter loss, and the development of...
This National Science Foundation Project Grant, awarded under the Engineering program (CFDA 47.041), provides $206,132 to Louisiana State University to conduct fundamental research on the high strain rate mechanics of the human brain. The research aims to develop advanced computational models and experimental techniques to better understand the complex mechanical behavior of the living human brain under extreme loading conditions, such as those encountered during traumatic brain injuries. The...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $768,427 supports a 3-year longitudinal study to determine the relationship between midlife vascular risk factors, cerebrovascular pulsatility, brain tissue integrity, and cognitive aging. The primary objectives are to: 1) determine the mechanisms leading to age-related increases in cerebrovascular pulsatility, 2) assess the spatial and temporal correlation between changes in...
This federal Project Grant award of $1,017,307 from the National Institute on Aging (under CFDA Program 93.866 - Aging Research) aims to leverage magnetic resonance elastography (MRE) to quantify brain mechanical properties as predictors of chronic subdural hematoma (CSDH) characteristics and brain tissue reexpansion after treatment.
The grant supports a study of 40 CSDH patients, collecting MRE data on brain stiffness and damping ratio along with standard clinical measures like hematoma size, density, and patient symptoms. The researchers will examine the correlation between the brain's mechanical properties in areas adjacent to the hematoma and factors like hematoma size/density and brain tissue reexpansion 1 month after treatment. This research could provide a valuable non-invasive biomarker to predict CSDH recurrence risk and enable more individualized treatment approaches.
The grant includes a $79,520 sub-award to Carle Foundation Hospital to support the medical research activities.