This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $211,875.00 to New York University School of Medicine to study the neuroanatomical abnormalities associated with repetitive head impacts in former American football players. The research aims to identify potential biomarkers and supportive features for diagnosing chronic...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports a $817,484 research project by Trustees of Boston University to characterize the spatial and temporal response to tau protein in chronic traumatic encephalopathy (CTE), a neurodegenerative disease linked to repetitive head injuries. The key objectives are to use cutting-edge approaches like single-nucleus RNA sequencing and spatial transcriptomics on brain tissue samples from the Boston...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Trustees of Boston University is supporting a comprehensive research study on the long-term health consequences of repetitive head impacts (RHI) across the lifespan. The $4,269,339 award, active from June 1, 2025 to May 31, 2027, is expanding the UNITE Brain Bank - the world's largest RHI and chronic traumatic encephalopathy (CTE) brain tissue repository - to investigate how RHI exposure, particularly...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $843,248 to support innovative research by Trustees of Boston University's Medical Campus. The primary objective is to develop computational algorithms to accurately identify chronic traumatic encephalopathy (CTE) pathology and spatially pinpoint heterogeneous...
This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $218,896.00 to Trustees of Boston University's Boston University Medical Campus to conduct research on neuroinflammatory alterations in post-traumatic stress disorder (PTSD) and chronic traumatic encephalopathy (CTE). The key objectives are to define microglia-mediated...
This $622,401 Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), will support a multi-arm research project to elucidate the causal sequence of brain biomarker changes leading to Alzheimer's disease (AD) and identify modifiable lifestyle factors that could delay disease onset. The key research objectives include: Developing advanced deep learning models to predict amyloid load from readily available single-shell diffusion MRI data in symptomatic and...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,756,811 from August 2024 to July 2029 to the University of Washington for the "NEUROIMAGING AND CLINICAL ENDPOINTS WITH HIGH-DIMENSIONAL ANALYSIS OF PATHOLOGICAL ENDOPHENOTYPES IN TBI (NEW-HOPE-TBI)" project. The goal is to build a biospecimen and data repository linked to brain tissues, biofluids, and clinical metadata from well-characterized research donors to enable...
This Cooperative Agreement award under the National Institute of Neurological Disorders and Stroke's (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $1,122,294 to Trustees of Boston University for research to determine the relationship between repetitive head impacts (RHI), traumatic brain injury (TBI), and neurodegenerative diseases such as Alzheimer's disease, Alzheimer's-related dementias, and chronic traumatic encephalopathy. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to investigate the relationship between traumatic brain injury (TBI), hematopoietic stem cell dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). The $102,948 award, active from December 1, 2024 to August 31, 2027, will employ a clinically...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a comprehensive research study titled "Risk and Resilience, Clinical Presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The Diagnose CTE Research Project II". The $6,578,788 award will be used to retain and expand an existing cohort of former football players and controls to examine the clinical features, biomarkers, and risk/resilience factors associated with chronic traumatic encephalopathy (CTE) and related dementias. Key activities include clinical evaluations, MRI, PET imaging, fluid biomarker analyses, and pathological validation through brain donation. The project involves a multi-site collaboration with sub-awards to institutions such as Mayo Clinic, University of Southern California, and Boston Medical Center to provide imaging analysis, data management, and clinical expertise. The goal is to refine diagnostic criteria for CTE and differentiate it from other neurodegenerative diseases, ultimately paving the way for improved detection, prognosis, and treatment of this condition.