This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering, under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, totals $580,654 and supports the development of an "Interferometric Diffuse Optics" (IDO) system to provide highly parallel and quantitative measurements of cerebral blood flow. The goal is to improve the ability to detect delayed cerebral ischemia, a major complication following subarachnoid hemorrhage. The proposed IDO system aims to increase the signal-to-noise ratio by 100x and the number of detection channels by 1000x compared to existing diffuse correlation spectroscopy approaches. This novel system will also provide time-of-flight information to account for anatomical variability and improve quantitative measurements of cerebral blood flow. The award period runs from December 2024 through November 2028, during which the awardee, New York University School of Medicine, will develop the IDO system, benchmark it against current technologies, and then deploy it for observational monitoring of subarachnoid hemorrhage patients in the neuro-intensive care unit.
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