This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $146,922 to the University of Southern California (USC) to conduct research aimed at purging mammalian cells of deleterious mutations in mitochondrial DNA (mtDNA). The research will utilize genetic and molecular biology tools, along with advanced sequencing techniques, to identify treatments that can selectively remove mtDNA mutations. This research has the potential to transform understanding...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $388,067 to support an interdisciplinary investigation of functional asymmetry and topological restructuring within mitochondrial networks during cellular aging. The primary awardee is Northwestern University, which will partner with the University of California, San Diego on the project. The research aims to mechanistically investigate how mitochondrial positioning and dynamics contribute to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and its effects on mitochondrial dysfunction in Alzheimer's disease. The primary goals are to: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics in mitochondria; and (2) Use optogenetic control of Aβ42...
The Scintillon Institute, a non-profit biomedical research organization, received a $529,650 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of the mitochondrial electron transport chain. The research aims to identify endogenous metabolites interconverted by NQO1 and characterize the bioenergetics of this alternative electron transfer mechanism, with the goal of developing therapeutic...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), is focused on investigating the mechanism by which mitochondrial protein import stress can induce myokine signaling, and how this may impact metabolic and cardiovascular health during aging. The $161,922 award, granted on December 20, 2024, will support research conducted by The Research Foundation for the State University of New York (SUNY), doing business as Upstate Medical...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University provides $2,672,656.00 in funding from August 15, 2024 through April 30, 2028. The project aims to leverage genetic variation, mitochondrial DNA copy number, metabolomics, and proteomics data from large biobanks to identify novel biomarkers and causal relationships between mitochondrial function and aging-related diseases like all-cause mortality, cardiovascular disease,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA, to conduct a 5-year study on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA mutations associated with cellular aging and age-related diseases. The research will utilize innovative long-read sequencing approaches to quantify...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...