This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $429,000.00 to the University of Texas Health Science Center at Houston to characterize the biochemical and biological properties of amyloid-beta (Aβ) misfolding in the eyes of Alzheimer's disease patients, and to evaluate the seeding potential of eye-derived Aβ using mouse models. The research aims to determine whether ocular exposure to misfolded Aβ, which has been identified in the eyes of Alzheimer's patients, could potentially lead to the transmission and acceleration of Alzheimer's pathology, similar to the way prion diseases spread. The project will utilize a range of in vitro and in vivo techniques, including biochemical and histological analyses, seeding experiments in mouse models, and behavioral assessments. The findings from this 2-year study could provide initial proof-of-concept evidence regarding the potential transmission risks associated with common medical procedures involving the eyes of Alzheimer's patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $429.0k | 3/28/25 |