Project Grant R21AG080592

Award Date 4/1/25
Completion Date 3/31/27
Dollars Obligated $429K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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The National Institute on Aging (NIA) awarded a $583,558 Project Grant (CFDA 93.866 - Aging Research) to the University of Alabama at Birmingham (UAB) to conduct research on retinal manifestations of Alzheimer's disease (AD). This 12-month project aims to: Track the earliest disease indicators of AD in the APP/PS1 mouse model through retinal testing. Define a range of normal retinal function in young and old human subjects. Evaluate the specificity and sensitivity of retinal tests in...
This Project Grant award of $246,750 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development of a novel "pulse-labeling" assay to track the secretion and spreading of extracellular vesicles (EVs) in the brains of mouse models. The goal is to better understand how EVs mediate the transmission of Alzheimer's disease-related proteins like amyloid-beta and tau. The assay will utilize fluorescent EV markers and cell-type specific promoters...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and mitochondrial dysfunction in Alzheimer's disease. The $308,000 award to the Regents of the University of Minnesota will pursue two specific aims: (1) examining the effects of Aβ42 on mitochondrial ribonucleoprotein granule dynamics, and (2) using optogenetic control to study the relationship...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,093,465 to The Washington University to conduct research on the relationship between synaptic activity and the generation and aggregation of amyloid-beta (Aβ) in Alzheimer's disease. The key objectives are to: Determine the threshold of synaptic activity that causes Aβ to aggregate into soluble oligomers and be released into the brain's interstitial fluid. Investigate whether...
This $466,531 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by Texas A&M AgriLife Research to investigate the role of the BIN1 protein in oligodendrocytes and its impact on axon integrity. The research aims to provide new insights into how the BIN1 genetic risk factor may relate to the onset and progression of late-onset Alzheimer's disease. The project will utilize oligodendrocyte-specific BIN1 knockout mice and a...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $429,000.00 to the University of Texas Health Science Center at Houston to characterize the biochemical and biological properties of amyloid-beta (Aβ) misfolding in the eyes of Alzheimer's disease patients, and to evaluate the seeding potential of eye-derived Aβ using mouse models.

The research aims to determine whether ocular exposure to misfolded Aβ, which has been identified in the eyes of Alzheimer's patients, could potentially lead to the transmission and acceleration of Alzheimer's pathology, similar to the way prion diseases spread. The project will utilize a range of in vitro and in vivo techniques, including biochemical and histological analyses, seeding experiments in mouse models, and behavioral assessments. The findings from this 2-year study could provide initial proof-of-concept evidence regarding the potential transmission risks associated with common medical procedures involving the eyes of Alzheimer's patients.

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