This $598,609 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to clinically evaluate mechanisms of resistance to the drug finasteride, commonly used to manage benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS). The primary objectives are to: (1) assess the efficacy of combination therapy (5α-reductase...
This $511,084 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to study the mechanisms of non-responsiveness to steroid 5a-reductase inhibitors (5ARIs) for the treatment of benign prostatic hyperplasia (BPH). The key objectives are to: 1) Elucidate that a specific luminal epithelial-2 (LE2) cell population is resistant to...
This $1,244,042 Project Grant awarded on August 1, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research - supports a center to validate mouse models of prostatic hyperplasia (BPH). The center will bring together three early-stage investigators with complementary expertise in mouse models, inflammation, and bioinformatics to develop new methods for correlating mouse transcriptomic data...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $897,666 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Old Dominion University (ODU) to investigate the role of lipid accumulation and foam cells in benign prostate disease. The research aims to elucidate the underlying pathogenesis of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in order to develop novel...
The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
This $318,488 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop and test optimized oral formulations to treat chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The funding will support studies in dogs and mice to identify a lead formulation with enhanced intestinal permeability and favorable pharmacokinetics, which can then...
This federal Project Grant award of $185,171 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) supports research to optimize polymeric chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) agents for detecting prostate cancer and benign prostate hyperplasia. The key objectives are to: 1) synthesize and characterize CEST MRI agents...
This $337,284 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support the development of a novel "Precision-Cut Bladder Slice" (PCBS) technology at Boston Children's Hospital. The goal is to enable quantitative assessment of bladder smooth muscle contraction, relaxation, and stiffness in both healthy murine and human tissues, while...
This Project Grant award for $690,451 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at the University of Pittsburgh to investigate the role of bladder fibroblasts, specifically suburothelial fibroblasts (SUFs), in regulating bladder function and sensation. The research aims to determine the molecular mechanisms by which SUFs...
This $521,019 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to evaluate and identify the communication between urothelial cells, sensory neurons, and the brain. The grant supports research at the Medical College of Wisconsin, Inc. to functionally and molecularly characterize the sensory neurons that respond to direct stimulation of...