This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting comprehensive scientific investigations into the biological, clinical, and sociobehavioral aspects of aging and age-related health conditions, with a focus on understanding the mechanisms of Alzheimer's disease (AD) and developing potential therapeutic approaches. The $2,114,698 grant, awarded to the University of North Texas Health Science Center at Fort Worth, will examine the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $462,923 to Albany Medical College to develop new mouse models of andropause (age-related decline in male sex hormones) to study its effects on Alzheimer's disease and related disorders. The project aims to determine the natural time course of endocrine aging in wild-type and Alzheimer's mouse models, and create two new mouse models of gradual androgen loss to more accurately reflect the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $242,310 to the University of Florida to conduct a research study examining the relationship between cognitive load, anterior cingulate cortex (ACC) activity, and the coupling of the striatal and hippocampal brain networks during age-related cognitive decline. The goal is to better understand the neural mechanisms behind the shift from hippocampus-dependent to striatum-dependent learning...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $212,095 aims to investigate changes in cholinergic modulation during aging and their impact on neural network activity and memory function in the hippocampus of young and aged mice. The key deliverables include: Acquiring high-quality experimental data on neural firing patterns and cholinergic dynamics in the hippocampal CA3 region of mice performing a spatial memory task, using...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $1,558,726.00 to the University of Pittsburgh for a longitudinal study investigating the neurobiological changes associated with the menopause transition in women. The study aims to elucidate brain and cognitive changes during the perimenopause stage, as well as the contributing factors such as menopausal symptoms, cardiovascular health, and sex hormones. Key deliverables include...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $434,500.00 in funding to the Research Foundation of the City University of New York (RFCUNY) from September 1, 2024 to June 30, 2026. The award will support research to investigate how age-related decline in dopamine neuron function impacts memory interference in the lateral entorhinal cortex (LEC) of older mice. Key objectives include: 1) Measuring dopamine transients in the LEC during...
This $1,333,623 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to determine whether stimulation of estrogen-sensitive neurons in the hypothalamus can mitigate sex differences in frailty and associated neuroinflammation in aging female mice. The researchers at the University of California, San Francisco (UCSF) will use CRISPR-based gene activation to increase physical activity levels in these neurons and assess downstream effects on frailty...
This $1,294,013 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year clinical trial and associated research examining the impact of biological aging mechanisms on exercise response variability in older adults. The principal investigator will conduct a randomized trial of a 6-month resistance training intervention and a health education control, focusing on two co-primary outcomes: physical function and insulin sensitivity. The project will...
This $153,056 federal Project Grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research on the neurocognitive mechanisms underlying age-related declines in episodic memory representational specificity. The project aims to: (1) identify EEG correlates of variations in episodic memory specificity among young and older adults, (2) use computational modeling to understand the cognitive processes accounting for these variations, and (3)...
This Project Grant award, titled "LONG-TERM EFFECTS OF EDUCATIONAL INVESTMENTS ON COGNITIVE HEALTH," is funded by the National Institute on Aging (CFDA 93.866 Aging Research program) in the amount of $3,519,439. The award period runs from August 1, 2024 to April 30, 2029. The grant aims to evaluate the causal effects of K-12 and college educational experiences, particularly in STEM and foreign language curricula, on late-life cognitive function and dementia risk. The project will...