Project Grant R21AA033529
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $1,887,924 on September 25, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and validate geroprotective precision medicine strategies targeting premature aging in people with HIV who use alcohol. The research identifies and tests personalized interventions addressing microbiota characteristics and senescent CD8+ T cells linked to clinical frailty in this...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $567,832 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research on reducing alcohol drinking through a nonmuscle myosin II small-molecule inhibitor targeting alcohol use disorder. The research focuses on disrupting alcohol-seeking and drinking behaviors in alcohol-dependent animal models using a first-in-class nonmuscle myosin II inhibitor...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center-Shreveport $321,929 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. The recipient will conduct research into nitric oxide regulation and its role in alcohol tolerance development. The work employs operant conditioning and behavioral testing in mouse models, including medial prefrontal cortex-specific neurogranin knockout and overexpression variants, to investigate...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Administrators Of Tulane Educational Fund (doing business as Tulane University) $401,626 on September 26, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate plasma membrane rupture in alcohol-associated hepatitis. The recipient will determine the role of plasma membrane rupture (PMR) in alcohol-associated liver disease and investigate the mechanism by which cholestasis promotes hepatocellular PMR in that...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), a division of the Department of Health and Human Services National Institutes of Health, awarded Yale University $663,419 on August 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate liver sinusoidal endothelial cell (LSEC) inflammation in alcohol-associated liver disease. The research addresses mechanisms by which alcohol disrupts LSEC homeostasis through two converging pathways: IL6 trans-signaling mediated...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas Health Science Center at Houston $1.772 million on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and validate a microbial-based platform for assessing alcohol-related organ damage in alcohol use disorders. The recipient will develop a comprehensive web-based knowledge module integrating microbiota, metabolites, and host pathways to map microbial signatures and mechanisms...
- The National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health within the Department of Health and Human Services, awarded $682,736 to Beth Israel Deaconess Medical Center, Inc. on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate myeloid-derived suppressor cells (MDSCs) in alcohol-associated steatohepatitis. The award funds research characterizing MDSC phenotypes and immunoregulatory capacity in alcohol-associated hepatitis...
- The National Institute on Alcohol Abuse and Alcoholism awarded Loyola University of Chicago Health Sciences Campus $470,066 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct basic research on the molecular mechanisms by which ABL kinase 2 (ABL2) contributes to alcohol-associated liver disease pathogenesis. The research will investigate three specific areas: the molecular mechanisms by which ABL2 promotes alcohol-induced steatosis; the role of ABL kinases in...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $158,600 on November 3, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research identifying the mechanisms underlying alcohol-induced hyperalgesia in adult rats. The project period runs through August 31, 2028, with work performed in New Orleans, Louisiana. The award funds experimental research examining how chronic adolescent alcohol exposure...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $488,077 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate molecular and functional adaptations in the nucleus reuniens, a midline thalamic region implicated in alcohol-related cognitive deficits. The research addresses how chronic alcohol exposure produces cognitive dysfunction that impairs treatment outcomes and increases relapse risk. The project will...
The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $215,625 under the Alcohol Research Programs (CFDA 93.273) on August 11, 2026. The award funds research exploring mitochondrial defense mechanisms against ethanol-induced dicarbonyl stress in the heart. The project investigates how the mitochondrial protein ES1 (glutamine amidotransferase domain-like 3A) protects cardiac tissue from chronic alcohol-related injury by preventing the accumulation of reactive dicarbonyl species such as glyoxal and methylglyoxal, which impair mitochondrial oxidative phosphorylation and drive alcohol-associated cardiomyopathy. Specific Aim 1 uses cardiac-specific ES1 knockout and AAV9-mediated ES1 re-expression models in mice exposed to chronic plus binge ethanol feeding to determine how mitochondrial ES1 modulates advanced glycation end product accumulation, mitochondrial respiration, and cardiac remodeling. The work is performed in New Orleans, Louisiana through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $215.6k | 8/13/26 |