Project Grant R01AA033269
Award Date 9/1/26
Completion Date 5/31/31
Dollars Obligated $488K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Charleston, SC 29425, USA
Similar Awards
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $151,040 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate orexinergic neuronal circuits and their role in alcohol dependence and excessive ethanol consumption. The project examines functional changes in orexinergic activity in male and female mice following chronic intermittent ethanol exposure, with particular focus on the lateral hypothalamic area-ventral...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $149,190 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to explore the role of medial prefrontal cortex corticotropin-releasing factor circuitry in stress-enhanced alcohol consumption. The research examines how chronic alcohol exposure and chronic stress alter corticotropin-releasing factor (CRF) and CRF receptor 1 (CRFR1) neurons in the prelimbic cortex, a key brain...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $154,300 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate neuroplasticity as a mechanistic link between adverse life experiences and adolescent alcohol use. The project leverages the Adolescent Brain Cognitive Development Study through three specific research aims. Aim 1 examines whether adverse experiences during adolescence alter neuroplasticity in...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $195,912 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate oleoylethanolamide (OEA) as a therapeutic intervention for alcohol use disorder in young adults. The recipient will conduct a randomized, double-blind, placebo-controlled clinical trial evaluating six weeks of OEA supplementation at 125 milligrams per day in 42 young adults ages 18 to 25 with alcohol...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Health Science Center at San Antonio $664,792 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate post-transcriptional mechanisms and cellular senescence in age-related alcoholic liver disease. The research targets dysregulated nutrient sensing as a hallmark of aging that drives hepatic steatosis progression toward cirrhosis and hepatocellular carcinoma. The recipient will...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Mississippi Medical Center $409,500 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate morphological and molecular alterations at nodes of Ranvier in alcohol use disorder. The research examines whether alcohol abuse in humans with alcohol use disorders and in experimental rats produces alterations in node of Ranvier morphology and distribution of extracellular matrix molecules...