Project Grant R01AA032764
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under CFDA 93.273 - Alcohol Research Programs provides $603,499.00 to the University of Texas Health Science Center at Houston (UTHealth) to develop a comprehensive, web-based knowledge module that integrates microbiota, metabolite, and host pathway data to map microbial signatures and mechanisms involved in alcohol-related organ damage (AROD). The project aims to define "alcohol enterotypes"...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a 1-year, $750,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to Tulane University, effective September 5, 2025. The grant supports research aimed at understanding the role of lactate and lactylation in the development and progression of HIV-related neurocognitive disorders, particularly in the context of aging among people living with HIV. Key aspects of the research...
- The Project Grant award of $131,654 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) is funding the development of a Lactobacillus-vectored alkaline phosphatase (AP) to mitigate alcohol-induced leaky gut and lipopolysaccharide (LPS) endotoxin load in the gut. The project aims to apply a two-pronged approach using: 1) Lactobacillus-based drug delivery technology to prevent alcohol-induced gut leakiness, and 2) the delivery of...
- This Project Grant award of $123,045.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research on the role of the TRAF3IP2 protein in the development of alcohol-related cardiomyopathy. The project will investigate whether alcohol-induced cardiac fibroblast activation, proinflammatory cytokine expression, and extracellular matrix changes are dependent on TRAF3IP2, and whether deleting the TRAF3IP2 gene prevents alcohol-induced...
- The Aging Well with HIV through Alcohol Research and Risk Reduction and Education (AWAR3E) Center is a $1,493,442 Project Grant awarded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs) on September 10, 2025. The grant supports a collaborative research initiative across four HIV cohorts to characterize "inflammaging" and associated geriatric syndromes among people with HIV. The Center will investigate novel biomarkers of inflammaging,...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $703,644 to the Icahn School of Medicine at Mount Sinai to investigate the drivers of accelerated aging in people living with HIV (PWH). The research aims to study the effects of HIV and antiretroviral therapy on epigenetic aging and clonal hematopoiesis, as well as examine the role of socio-behavioral factors and genetic predisposition in...
- This Project Grant award of $429,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Colorado-Denver aims to investigate the relationship between gut microbiota dynamics, exercise, and physical function among older adults with HIV. The research project will examine how exercise-induced changes in the gut microbiome may contribute to improvements in physical function for this population, which has been observed to experience impairments in physical...
- The Southeast Translational Alcohol and HIV Research (STAHR) Center was awarded a $1,785,057 Project Grant by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) to conduct three inter-related clinical trials and observational studies focused on reducing alcohol consumption and mitigating alcohol's harmful effects on cardiovascular disease risk among people living with HIV. The key objectives are to: 1) examine the association between alcohol, gut...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,593,618 Project Grant under the Alcohol Research Programs (CFDA 93.273) to establish the Center for Alcohol/HIV Innovations and Biomarker Research (CALIBER) at the University of California, San Francisco (UCSF). The goal of CALIBER is to (1) reduce the harmful effects of alcohol use on HIV prevention and HIV-associated comorbidities, (2) advance innovations in alcohol measurement, and (3) train the next generation of...
- This federal Project Grant award, provided by the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support program), will support a mixed-methods research study to understand the interplay of social and physical environments, loneliness, and cognition among older people living with HIV. The $123,579 award, with a performance period from June 15, 2025 to March 31, 2030, will be administered by Northeastern University. The research aims to...
This $634,829 Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project titled "Geroprotective Precision Medicine Strategies in PWH that Use Alcohol". The project aims to identify personalized approaches to overcoming inconsistent responses to microbiota-targeted interventions and validate their capacity to offset mechanisms of biological aging in people with HIV (PWH) who consume alcohol. The award was made to Louisiana State University Health Sciences Center New Orleans, a prominent U.S. state government educational institution and academic medical center, and will run from Sep 25, 2025 through Aug 31, 2030. The project will test two generally recognized as safe (GRAS) treatments, a Lactobacillus reuteri probiotic and a blueberry-based antioxidant mix, to mitigate the effects of alcohol use on the microbiome and immune system in PWH.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $634.8k | 9/24/25 |