Project Grant R21AA032964
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $706,409 under the Alcohol Research Programs (CFDA 93.273) on September 1, 2026, to examine the neurobiological mechanisms linking sexual assault victimization to alcohol use disorder risk in college-aged adults. The study will recruit 220 heavy-drinking participants aged 21–29, divided into two groups: those with a history of sexual assault and those without. Researchers will conduct three laboratory...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $1,771,875 under the Alcohol Research Programs (CFDA 93.273) on August 4, 2026, for research into the novel mechanism of nuclear histone deacetylase 4 (HDAC4) in early-life stress-induced alcohol consumption, preference, and tolerance in offspring. The research develops a mouse model using offspring born to dams that experienced prenatal restraint stress during pregnancy to investigate how early-life...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $628,080 under the Alcohol Research Programs (CFDA 93.273) on May 1, 2026. This Project Grant (R01AA032487) funds a five-year investigation into whether a hyperactive nociceptin opioid peptide receptor (NOP) system drives relapse in heavy drinking alcohol use disorder (AUD) subjects, using positron emission tomography imaging with [11C]NOP-1A radiotracer and hydrocortisone challenge protocols. Prior...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $474,223 on May 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to elucidate brain region- and cell-specific mechanisms of alcohol-induced developmental neurotoxicity and develop precision interventions targeting neuroprotection. The research addresses fetal alcohol spectrum disorder (FASD), which contributes significantly to intellectual disabilities with a prevalence rate of 1-5% in the...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $1,390,966 on September 18, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct a randomized, double-blind, placebo-controlled clinical trial testing suvorexant as a novel therapeutic for alcohol use disorder and stress-related drinking. The trial will enroll 250 treatment-seeking individuals with current alcohol use disorder and randomize participants to eight weeks of 10 milligrams nightly...
- The National Institute on Alcohol Abuse and Alcoholism awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $1,156,082 under the Alcohol Research Programs (CFDA 93.273) on September 25, 2025, to investigate the gut-brain axis and the role of butyrate in neuroinflammation and pain sensitivity. The research examines the relationship between alcohol use disorder, chronic pain, gut dysbiosis, and neuroinflammation, with focus on how gut microbial-derived short-chain...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Mississippi Medical Center $930,571 on September 23, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate behavioral responses to opioid-alcohol combinations and the role of mu opioid receptor neurogenetic variation in vulnerability to combined substance use. The research evaluates how a functional variant of the mu opioid receptor (C77G polymorphism) in genotyped rhesus monkeys influences...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $578,234 on August 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to establish a translational human laboratory model investigating alcohol's effects on pain in persons with co-occurring alcohol use disorder and chronic pain. The research uses a computer-controlled intravenous alcohol clamp to quantify alcohol's biphasic effects on pain perception—analgesia during the ascending phase and hyperalgesia...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Colorado, doing business as University of Colorado-Denver, $1,162,583 on September 10, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct research combining laboratory-based pain induction and ecological momentary assessment (EMA) methods to examine age-related differences in the relationship between alcohol use, pain, and inflammation. The research tests two hypotheses: that pain...
The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $226,406 on August 10, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate pain sensitivity, alcohol-induced analgesia, and heavy drinking in individuals with opioid use disorder. The research addresses a critical gap in understanding mechanisms that drive concurrent alcohol and opioid use, which occurs at rates 13 times higher in individuals with opioid use disorder compared to the general population and substantially increases overdose risk and worsens treatment outcomes. The study will recruit 90 participants into three groups: individuals with current opioid use disorder who engage in heavy alcohol use, individuals with current opioid use disorder without heavy alcohol use, and heavy drinkers without opioid use history. Participants will complete three experimental laboratory sessions separated by 2 to 7 days to test hypotheses during both sobriety and alcohol intoxication, with assessments including multimodal measures of pain and affect. The award supports the hypothesis that substance-induced hyperalgesia may motivate concurrent alcohol-opioid use while increasing responsiveness to alcohol's analgesic effects. Performance occurs in Columbus, Ohio. The period of performance runs from the award date through July 31, 2028. This is a Project Grant, an assistance type supporting specified research projects recommended for approval by the National Advisory Council on Alcohol Abuse and Alcoholism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $226.4k | 8/12/26 |