Project Grant R01AA032917
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Colorado, doing business as University of Colorado-Denver, $1,162,583 on September 10, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct research combining laboratory-based pain induction and ecological momentary assessment (EMA) methods to examine age-related differences in the relationship between alcohol use, pain, and inflammation. The research tests two hypotheses: that pain...
- The National Institute on Alcohol Abuse and Alcoholism, under the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Minnesota $400,585 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the spinal mechanisms of alcohol-induced tactile hypersensitivity. The research addresses the relationship between chronic alcohol consumption and heightened pain sensitivity in individuals with alcohol use disorder. The...
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $158,600 on November 3, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research identifying the mechanisms underlying alcohol-induced hyperalgesia in adult rats. The project period runs through August 31, 2028, with work performed in New Orleans, Louisiana. The award funds experimental research examining how chronic adolescent alcohol exposure...
- The National Institute on Alcohol Abuse and Alcoholism awarded Boston Children's Hospital $489,479 under Project Grant R21AA033213 on August 1, 2026, to characterize physical and emotional pain during protracted withdrawal from alcohol use disorder and identify predictive factors and brain-behavior mechanisms underlying these pain syndromes. The research addresses a gap in understanding how physical pain (musculoskeletal, phantom pain) and emotional pain (hyperkatifeia, stress, anhedonia, social...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $226,406 on August 10, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate pain sensitivity, alcohol-induced analgesia, and heavy drinking in individuals with opioid use disorder. The research addresses a critical gap in understanding mechanisms that drive concurrent alcohol and opioid use, which occurs at rates 13 times higher in individuals with opioid use disorder compared to the...
- The National Institute on Alcohol Abuse and Alcoholism awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $1,156,082 under the Alcohol Research Programs (CFDA 93.273) on September 25, 2025, to investigate the gut-brain axis and the role of butyrate in neuroinflammation and pain sensitivity. The research examines the relationship between alcohol use disorder, chronic pain, gut dysbiosis, and neuroinflammation, with focus on how gut microbial-derived short-chain...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $752,580 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a five-year experimental medicine trial examining semaglutide dose effects on metabolic dysfunction, stress hormones, craving, and alcohol use outcomes in individuals with comorbid alcohol use disorder and obesity. The trial compares semaglutide at 1 milligram and 2 milligram doses against placebo over a 20-week treatment period and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $100,228 under the Alcohol Research Programs (CFDA 93.273) on October 27, 2026, to investigate the neurobiological mechanisms underlying the co-occurrence of alcohol use disorder and post-traumatic stress disorder. The project examines how stress exposure disrupts excitation-inhibition balance in the medial prefrontal cortex, driving increased alcohol consumption and heightened motivation for alcohol use. Using single...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), a division of the Department of Health and Human Services National Institutes of Health, awarded Yale University $663,419 on August 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate liver sinusoidal endothelial cell (LSEC) inflammation in alcohol-associated liver disease. The research addresses mechanisms by which alcohol disrupts LSEC homeostasis through two converging pathways: IL6 trans-signaling mediated...
The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $578,234 on August 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to establish a translational human laboratory model investigating alcohol's effects on pain in persons with co-occurring alcohol use disorder and chronic pain. The research uses a computer-controlled intravenous alcohol clamp to quantify alcohol's biphasic effects on pain perception—analgesia during the ascending phase and hyperalgesia during the descending phase of alcohol consumption—at standardized breath alcohol concentration windows. The study enrolls 112 adults across four groups: healthy controls, alcohol use disorder only, chronic pain only, and both conditions combined. Participants undergo two counterbalanced, double-blind sessions separated by three days, receiving placebo and IV alcohol targeting 0.10 g/dL breath alcohol concentration. Primary pain assessment occurs via heat pain threshold, with conditioned pain modulation and temporal summation of pain indexing pain-modulatory mechanisms. The research tests whether the co-occurrence of alcohol use disorder and chronic pain produces the most adverse pain response profile and whether laboratory findings translate to real-world pain-drinking dynamics. Work is performed in New Haven, Connecticut. The period of performance runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $578.2k | 8/21/26 |