Project Grant R01AA031498
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $105,132 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kentucky Research Foundation. The grant, titled "Uncovering the Functional and Mechanistic Dysregulation of Monocytes After Abstinence and Post-Abstinence Drinking," will leverage a rhesus macaque model to investigate the persistent functional, transcriptional, and epigenetic changes in peripheral monocytes induced by...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a Project Grant of $180,939 to Yale University on September 1, 2025. The grant funding will support a study examining neurobiological threat reactivity as a potential biomarker for the comorbidity of chronic pain and alcohol use disorder (AUD). The project aims to use functional neuroimaging to investigate how the anterior insular cortex circuit function correlates with...
- This $232,316 Project Grant awarded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research to investigate the role of a novel dynorphinergic circuit in the central amygdala and its connection to the nucleus accumbens. The research aims to understand how this circuit is modulated by chronic pain and fentanyl abstinence, and how it contributes to binge-like alcohol drinking behavior, pain-related cognitive effects, and reinstatement of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $152,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Des Moines University Osteopathic Medical Center (DMU) to study the role of GLUD1 receptors in regulating structural plasticity during chronic ethanol exposure and withdrawal. The two-year grant, awarded on September 1, 2023, will support DMU's research aimed at understanding how GLUD1 receptor function and expression influence dendritic spine...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
- This federal Project Grant award of $337,500.00, awarded on September 5, 2025 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), supports a research project titled "Kappa Opioid Receptor Modulation of BLA Inputs to the BNST and Stress-Escalated Drinking" under the NIAAA's Alcohol Research Programs (CFDA 93.273). The project aims to investigate the neural mechanisms by which social stress leads to increased alcohol consumption, with a focus on the role of the kappa...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $399,076 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Tennessee Health Science Center in Memphis, TN. The purpose of this grant is to develop a rapid and reliable platform for evaluating and repurposing FDA-approved drugs to target chronic alcohol tolerance and dependence associated with Alcohol Use Disorder (AUD). The project will leverage the nematode Caenorhabditis elegans as an...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $601,129 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The project, titled "Alcohol and Gut-Brain Axis and the Role of Butyrate on Neuroinflammation and Pain Sensitivity", aims to investigate the relationship between alcohol use disorder, chronic pain, and the gut microbiome, with a focus on the role of...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $571,673 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Mississippi Medical Center (UMMC). The funding supports research to investigate the combined behavioral effects of opioids and alcohol, and the potential role of a genetic variant of the mu opioid receptor (OPRM1 A118G) in influencing individual vulnerability to opioid-alcohol use and abuse. The research project will use rhesus monkeys genotyped for an orthologous receptor variant to evaluate how neurogenetic factors contribute to the reinforcing effects of opioids, alcohol, and their combination. This 5-year research study, awarded on September 23, 2025, aims to improve understanding of the mechanisms underlying problematic opioid-alcohol co-use and identify potential targets for more effective prevention and treatment strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $571.7k | 9/23/25 |