Project Grant R18EB035005

Award Date 9/30/23
Completion Date 9/29/26
Dollars Obligated $2.5M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), provides $2,505,537 to The Leland Stanford Junior University to develop a focused ultrasound (FUS) device for noninvasive, peripheral nerve blockade to manage acute pain. The goal is to provide an alternative to opioids and current peripheral nerve block techniques, which have significant limitations in acute pain management.

The project aims to: 1) determine the optimal FUS parameters for transcutaneous, reversible peripheral nerve blockade without adverse effects; 2) develop a FUS device with the appropriate frequency and focal zone geometry for application to non-human primate and human peripheral nerves; and 3) evaluate the use of transcutaneous FUS for reversible peripheral nerve blockade in a non-human primate model of acute pain. This research seeks to address key barriers preventing clinical trials on FUS-induced peripheral nerve blockade for acute pain management.

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