Project Grant R16GM159643
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $903,697 to the University of Nebraska at Omaha to conduct research aimed at understanding the neurophysiological mechanisms underlying chronic ankle instability. The objective is to determine functional and neurophysiological differences between subgroups of chronic ankle instability in order to develop more effective, evidence-based rehabilitation approaches. The research involves...
- This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative...
- This $530,469 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rowan University aims to investigate the role of the protein orosomucoid1 in mitigating age-related muscle loss and dysfunction (sarcopenia). The central hypothesis is that enhancing autophagy (a cellular process) through administering TAT-BECLIN1 and combining it with exercise will boost orosomucoid1 levels and improve muscle function in aged mice. The project seeks to determine if...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $880,000 to Old Dominion University from September 2024 through August 2026. The project aims to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in the context of chronic HIV infection. Specifically, the research will explore the impact of MGDR on brain pathology in HIV-infected mouse models, examining its...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This $665,970 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how mechanical loading protocols, such as exercise and nutrition, can regulate knee joint health and potentially ameliorate age-related knee osteoarthritis. The award will fund a 5-year research project conducted by an interdisciplinary team at The Spaulding Rehabilitation Hospital Corporation in Massachusetts. The project aims to use innovative approaches,...
- This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular...
- The National Institute on Aging (NIA) awarded a $639,997 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Spaulding Rehabilitation Hospital Corporation in Massachusetts on May 15, 2025. The grant supports a research project titled "Mechano-Regulation of Circulating Extracellular Vesicle Cargoes to Enhance Knee Joint Health" with a planned completion date of March 31, 2030. The project aims to investigate how physiological exercise regulates molecular...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $650,872 Project Grant to The Johns Hopkins University to investigate the bioenergetic, physiological, and gait mechanics mechanisms that contribute to the high energetic cost of walking in older adults. The 5-year project, which began on August 15, 2025, will use clinical, laboratory, and sensor-based assessments to detect changes in health and mobility consistent with the onset and...
- This $109,076 project grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) on November 27, 2025, aims to investigate the impact of modulating synovial mechanobiology to mitigate disease progression in osteoarthritis (OA). The project will evaluate the effect of genetic and pharmacologic suppression of non-muscle myosin II (NM-II) on fibroblast-like synoviocyte (FLS) activation, synovial fibrosis, and OA pathogenesis using in vitro and in vivo models. The research is...
This $154,969 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Old Dominion University (ODU) from August 2025 through June 2029. The purpose of the study is to determine the independent and interactive effects of chronic ankle instability (CAI) and aging on joint health, physical activity, balance, gait, reaction time, muscular strength, and perceived function. The longitudinal study will recruit 180 participants across three age groups (20-39, 40-59, and 60-79 years) and two injury history groups (CAI and control). The research aims to better understand the compounded impact of CAI and aging on physical function and daily activity levels. Old Dominion University Research Foundation (Odurf) will serve as a key partner in executing the study's research activities.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $155.0k | 8/19/25 |