Project Grant R01AG092299

Award Date 5/15/25
Completion Date 3/31/30
Dollars Obligated $640K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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The National Institute on Aging awarded a $1,997,858 Project Grant (CFDA 93.866 Aging Research) to The Spaulding Rehabilitation Hospital Corporation in Charlestown, MA. The grant, titled "The Opposing Effects of Matrix Aging and Muscle Activity on Extracellular Vesicle Promotion of Muscle Regeneration," aims to investigate how aging of the skeletal muscle extracellular matrix and muscle activity impact the molecular composition and function of extracellular vesicles in promoting muscle...
The National Institute on Aging (NIA) awarded a $426,250 Project Grant (CFDA 93.866 - Aging Research) to the Regents of the University of Minnesota to develop an organoid-derived exosome product for the treatment of osteoarthritis (OA). The objective is to leverage the immunoregulatory mechanisms in play during fetal development to identify the stage of multi-tissue organoid development that yields exosomes with anti-inflammatory and chondrocyte proliferation potential. The researchers will...
The National Institutes of Health (NIH) National Institute on Aging (NIA) awarded a $2,617,270 Project Grant (CFDA 93.866 - Aging Research) to Wake Forest University to conduct a 6-month remote behavioral intervention targeting weight loss, increased physical activity, and reduced sedentary time in older adults with chronic knee or hip osteoarthritic pain. The primary goals are to improve daily step counts, reduce pain interference, and enhance other health outcomes. The project builds on...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $299,428 Project Grant to WNT Scientific LLC to develop an innovative medical device to treat nonunion fractures in older adults. The device is a biodegradable, controlled-release material designed to promote fracture healing by stimulating angiogenesis (blood vessel formation), which is impaired in elderly patients due to chronic inflammation. The awarded project aims to commercialize this...
The National Institute on Aging (NIA) awarded a $1,545,208 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Florida Institute for Human & Machine Cognition Inc. (IHMC). The award, effective September 15, 2024 through August 31, 2029, will fund a multidimensional study to understand the factors contributing to exercise response heterogeneity in older adults. Specifically, the research will investigate how aging hallmarks such as proteostasis, mitochondrial...
This federal Project Grant award for $847,000 from the National Institute on Aging (NIA) Aging Research program (CFDA 93.866) aims to determine whether extracellular vesicles (EVs) containing the Y5-RNA mediate the age-dependent impairment of angiogenesis. Specifically, the award will: Examine whether Y5-RNA in endothelial cell-derived EVs mediates age-dependent induction of endothelial cell senescence. Determine whether Y5-RNA in endothelial cell-derived EVs mediates the age-dependent decline...
The National Institute on Aging (NIA) awarded a 5-year, $1,294,013 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic to study the impact of biological mechanisms of aging on response variability to resistance training in older adults. The research will conduct a randomized clinical trial to define the exercise response heterogeneity in physical function and insulin sensitivity, examining cellular senescence and DNA methylation in skeletal muscle. The project involves collaboration with...
The National Institute on Aging awarded a $1,023,154 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant supports a 5-year project to evaluate the effectiveness and implementation of neuromuscular electrical stimulation (NMES) to address musculoskeletal deficits after total knee arthroplasty (TKA). The project will compare outcomes between patients receiving contemporary rehabilitation with a...
This federal Project Grant award, with ID R01AG086058, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine. The $1,905,716.00 grant, awarded on August 1, 2024, will support a 5-year research project to investigate the molecular mechanisms regulating the inflammatory response in skeletal stem and progenitor cells, and the role of anti-inflammatory factors in resolving inflammation. The project aims to generate insights into...
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The National Institute on Aging (NIA) awarded The Spaulding Rehabilitation Hospital Corporation a $639,997 Project Grant under the Aging Research federal grant program (CFDA 93.866) to conduct research on the mechano-regulation of circulating extracellular vesicle cargoes to enhance knee joint health. The 5-year grant aims to investigate how exercise regulates molecular pathways in cartilage and surrounding knee joint tissues, with the goal of promoting more youthful molecular cargoes within circulating extracellular vesicles to directly or indirectly improve cartilage integrity and knee joint health, particularly in the context of knee osteoarthritis. The research will leverage innovative multi-omics analysis and a mouse model of female aging to provide mechanistic insights on the impact of circulating factors on knee joint health.

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