This Project Grant award of $633,671 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, supports research on the safety of prescription sleep medications in children, adolescents, and young adults with Attention Deficit Hyperactivity Disorder (ADHD). The key objectives are to: 1) Evaluate nationwide patterns of prescription sleep medication use and dose-escalation in youth with ADHD; 2) Determine the extent to which these...
This federal Project Grant award of $809,312, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to characterize circadian function and identify circadian dysfunction among children with Attention-Deficit/Hyperactivity Disorder (ADHD). The primary objectives are to: 1) Assess individual differences in circadian function and sleep profiles using laboratory-based dim light melatonin onset (DLMO) assessment and wearable...
This federal Project Grant award of $826,902 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the dynamic relationships of physical activity, sleep, and circadian rhythms with heterogeneity in clinical symptoms and neurobehavioral functioning in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The award will fund a micro-longitudinal study leveraging wearable technology to objectively track daily...
The National Institute of Mental Health (NIMH) awarded a 5-year, $857,216 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to study the neurodevelopmental trajectories leading to early symptoms of Attention Deficit Hyperactivity Disorder (ADHD) and disruptive behaviors in socioeconomically disadvantaged, racially and ethnically diverse children. The key objectives of this project are to: 1)...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to assess the impacts of a 2022 nationwide shortage of immediate-release formulations of amphetamine mixed salts, a class of prescription stimulant medications, on the health outcomes and disparities of youth with Attention-Deficit Hyperactivity Disorder (ADHD). The $729,367 award, granted to The RAND Corporation, will fund a comprehensive research...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $458,452 to the University of Utah to conduct research on the interrelationship between sleep, circadian rhythms, and substance use disorders. The key objectives are to: 1) determine the mechanisms of psychostimulant-induced sleep changes, 2) screen Drosophila orthologs of human brain-enriched transcripts for their role in...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund a 5-year study to examine the relationship between parent-child neurobehavioral synchrony and early trajectories of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in preschool-aged children. The $673,803 award, starting on December 1, 2024, will support the University of Pittsburgh in using functional near-infrared spectroscopy (fNIRS)...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding a $424,875 research project titled "Adolescent Trauma Produces Enduring Disruptions in Sleep Architecture that Lead to Increased Risk for Adult Mental Illness." The project aims to: 1) determine if individual differences in sleep profiles following adolescent stress can predict adult behavioral outcomes related to depression and...
This Project Grant award of $1,541,456 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, supports a study to elucidate the neurobiological mechanisms of estrogen effects on cognition and ADHD symptoms in young adult females with ADHD. The project aims to use an intensive longitudinal menstrual cycle study design to evaluate how menstrual cycle phase and hormonal effects on neural circuitry involved in response inhibition and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $443,671 to The Lieber Institute for Brain Development (LIBD) to investigate the molecular, cellular and circuit-level mechanisms underlying sustained attention deficits observed in neuropsychiatric disorders. The research leverages genetic and circuit-specific tools to dissect the role of the locus coeruleus-anterior cingulate cortex circuit and the...