This $1,432,724 federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund a research study examining the developmental impacts of sleep patterns on positive valence systems and socioemotional functioning during pre-adolescence. The study consists of two components: 1) a one-year longitudinal burst design with a non-clinical sample of 290 youth aged 8-12 to assess behavioral and neurophysiological...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Research Institute at Nationwide Children's Hospital (RINCH). The $195,000 award, effective May 1, 2025 through April 30, 2027, will fund a research project titled "Characterizing the Role of Sleep Brain Dynamics in the Emergence of Depression in Adolescents". The project aims to identify space-time profiles of slow oscillations and sleep...
This Project Grant award from the National Institute of Mental Health (NIMH, CFDA 93.242 Mental Health Research Grants) provides $588,018 to The Trustees of the University of Pennsylvania to investigate the neural basis of how stress impacts sleep architecture and cognition. The key focus is to determine how inputs from stress-regulatory neurons in the locus coeruleus and paraventricular nucleus of the hypothalamus disrupt specific features of sleep, such as microarousals and REM sleep...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, will support a study on "Sleep as a Mechanism of Premenstrual Exacerbation of Depression and Suicidality." The $162,486 award, effective December 27, 2024 through June 26, 2028, will utilize high-resolution digital health sleep data from a recently completed clinical trial to examine the role of sleep disturbances as a potential physiological mediator...
This Project Grant award of $793,161.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a study on the relationship between nocturnal wakefulness and suicide risk. The study aims to experimentally examine how mood, neuropsychological function, and suicidality are impacted by circadian rhythms and homeostatic sleep pressure, particularly during the 2-4am timeframe. The project will recruit 90 adults with a history of...
The National Institute of Mental Health (NIMH) awarded a $2,809,928 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Pittsburgh to conduct a multi-site, double-blind, randomized-controlled efficacy trial of a transdiagnostic intervention for sleep and circadian dysfunction to improve depression symptoms in older adults with high suicide risk. The study aims to confirm the target engagement and efficacy of this intervention, as well as develop an algorithm to...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on evaluating the safety of prescription sleep medications in children, adolescents, and young adults with Attention Deficit Hyperactivity Disorder (ADHD). The $633,671 award to Rutgers, The State University of New Jersey, will fund a 5-year study (May 1, 2025 - Feb 28, 2030) to: 1) examine nationwide patterns of sleep medication use and dose...
This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), is funding a $792,441 research project to investigate the dynamic trajectory of behavioral, physiological, and neurobiological stress responses in female adolescents at high and low familial risk for depression. The project aims to track changes in default mode network (DMN) and central executive network (CEN) brain activity, as well as...
This Project Grant award, with Federal Grant ID R21MH134016, is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The $408,541 award supports research at Drexel University to investigate the role of retrosplenial cortex (RSC) layer-5 neurons in initiating slow-wave sleep (SWS) up states to facilitate memory consolidation. The research aims to advance the understanding of RSC neuronal activity dynamics and delta oscillation...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a $121,424 study examining the relationship between early sleep disruption, functional brain networks, and developmental trajectories in infancy. The study will leverage data from two longitudinal NIH-funded projects - the Infant Brain Imaging Study (IBIS) and the Healthy Brain and Child Development (HBCD) Study - to (1) investigate how...