This $2,153,762 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to validate electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention. The primary objectives are to optimize a rodent continuous performance test (rCPT) to study the impact of target percentage on vigilance decrement, evaluate the optimized rCPT using the stimulant amphetamine,...
This federal Project Grant award of $582,487, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the circuit and behavioral roles of parvalbumin-expressing GABAergic neurons in the basal forebrain to support sustained attention. The objective is to determine how this understudied basal forebrain neuron population contributes to cognitive functions like sustained attention, distinct from the known roles of...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will support research to investigate the biological mechanisms underlying attention control and information processing. The $864,475 award will enable The Trustees of Columbia University in the City of New York to: Provide behavioral evidence for the...
The National Institute of Mental Health (NIMH) awarded a $1,978,475 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Trustees of Princeton University to study the neural basis of visual attention in the primate brain. The grant, with an award date of August 6, 2024 and ultimate completion date of April 30, 2029, will investigate the temporal dynamics and neural mechanisms underlying visual attention, including how low-frequency rhythms coordinate sensory and motor processes....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,018,778 to The Lieber Institute for Brain Development (LIBD) to generate spatially-resolved, transcriptome-wide gene expression profiles of the human dentate gyrus across the lifespan. The project aims to characterize developmental and age-related changes in gene expression within specific subregions of the hippocampus, a critical brain structure involved in learning, memory, and...
The federal Project Grant award K99MH137314, totaling $127,305, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award is supporting research by the Icahn School of Medicine at Mount Sinai to investigate the role of frontal parvalbumin interneuron maturation in the development of attentional abilities from adolescence to adulthood. The research aims to characterize how the maturation of these specific neurons in the...
This $908,174 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to improve understanding of the cellular and molecular mechanisms underlying schizophrenia. The primary objectives are to: 1) Replicate and expand on prior findings regarding associations between electrophysiological variables in patient-derived induced pluripotent stem cell (iPSC) models and clinical/cognitive phenotypes of...
The National Institute of Mental Health (NIMH) awarded a $267,310 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Trustees of Boston University's Medical Campus to study inhibitory neurotransmission in the prefrontal cortex of rhesus macaques. The research aims to understand how compartment-specific inhibition and laminar circuit dynamics in the lateral prefrontal cortex (LPFC) and anterior cingulate cortex (ACC) contribute to cognitive and emotional disturbances in...
This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $1,425,651 in funding to the University of Maryland, Baltimore (UMB) to support a research project investigating the neural circuit mechanisms underlying interactions between distinct learning systems in the brain. The project aims to identify task components that drive learning interactions, determine the neural activity dynamics in the prefrontal cortex during...
This $857,216 federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants will be used by Boston Children's Hospital to conduct a longitudinal study examining the neurodevelopmental trajectories and social determinants leading to early symptoms of Attention Deficit Hyperactivity Disorder (ADHD) and disruptive behaviors in children. The study will leverage an existing large, diverse cohort of low-resourced infants seen in an...