The National Institute of Mental Health (NIMH) awarded a 5-year, $809,312 Project Grant to Duke University under the Mental Health Research Grants program (CFDA 93.242) to characterize circadian function and its associations with clinical presentation and cognition in children with Attention-Deficit/Hyperactivity Disorder (ADHD). The project aims to: 1) Use gold-standard dim light melatonin onset (DLMO) assessments and actigraphy to evaluate individual differences in circadian function and...
The National Institute of Mental Health (NIMH) awarded a $857,216 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Children's Hospital Corporation, doing business as Boston Children's Hospital, for a longitudinal study titled "Longitudinal EEG and Environmental Trajectories Leading to ADHD and Disruptive Behaviors from Infancy to Preschool". The 5-year study, starting December 1, 2024, aims to characterize the neurodevelopmental trajectories leading to early...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support a study on the impact of early-life psychostimulant exposure on sleep neurophysiology and circadian rhythms in an animal model of ADHD. The $181,234 grant will fund two main studies: 1) investigating the effects of methylphenidate on sleep architecture and neurophysiological activity in preadolescent and adult rodent...
This federal Project Grant award from the National Institute of Mental Health's Mental Health Research Grants program (CFDA 93.242) in the amount of $2,535,618 will fund a study to advance the understanding of the genetic underpinnings of primary attention-deficit/hyperactivity disorder (ADHD). The key objectives are to: 1) develop the largest family-based repository of children with primary ADHD and their family members using consistent diagnostic criteria, 2) identify novel candidate genes...
This $367,708 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research on the neural underpinnings of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). The University of Southern California (USC) will use cutting-edge functional MRI techniques and advanced machine learning methods to investigate how connectivity patterns in the brain's reward circuitry differ...
The University of Pittsburgh was awarded a $673,803 Project Grant under the National Institute of Mental Health's Mental Health Research Grants program (CFDA 93.242) to study the relationship between parent-child neurobehavioral synchrony and the development of ADHD symptoms in preschool-aged children. The 5-year grant, which commenced on December 1, 2024, will utilize functional near-infrared spectroscopy (fNIRS) to examine how parent-child focused attention and neural synchrony impact the...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $615,908 over 3 years to Nurelm, Inc. to develop and test the LEMURDX system. LEMURDX is a software platform that uses machine learning and wearable device sensors to objectively measure hyperactivity in children with ADHD. The project aims to refine the LEMURDX product to enhance its usability for clinical researchers, and to test the system's...
The National Institute of Mental Health (NIMH) awarded a $671,533 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Childrens Hospital Medical Center in Cincinnati, Ohio. The grant, titled "ADHD PRESMART: ADHD PRESMA RESPONSE INHIBITION THERAPY", aims to use accelerated intermittent theta-burst transcranial magnetic stimulation (iTBS) to target the pre-supplementary motor area of the brain in adolescents with ADHD. The goal is to modulate inhibitory network...
The National Institute of Mental Health (NIMH) awarded a $753,016 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Lieber Institute for Brain Development to validate electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention. The 5-year project, starting on July 10, 2024, aims to optimize a rodent continuous performance test (CPT) paradigm, evaluate the impact of amphetamine on electrophysiological correlates of behavior, and...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Children's Hospital of Philadelphia (CHOP) in the amount of $239,144 with a start date of August 6, 2024 and an end date of June 30, 2027.
The purpose of this grant is to develop and pilot test caregiver-facing implementation strategies (called Supporting School Success for Caregivers or SSS-C) to support caregivers of children with or at-risk for...
The National Institute of Mental Health (NIMH) awarded a $826,902 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to examine the dynamic relationships between physical activity, sleep, and circadian rhythmicity with neurobehavioral heterogeneity in attention-deficit/hyperactivity disorder (ADHD). The 5-year grant, awarded on May 1, 2025 and running through April 30, 2030, will leverage wearable technology to objectively track daily activity, sleep, and circadian patterns in a well-characterized sample of 200 children (100 with ADHD, 100 typically developing controls). The study aims to elucidate how these factors relate to the clinical symptoms, cognitive functioning, and brain structure/function associated with the heterogeneity observed in ADHD. Findings will inform the development of targeted interventions using wearable technology to improve outcomes for individuals with ADHD.