This $1,541,456 project grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to elucidate the neurobiological mechanisms by which changes in estrogen and progesterone levels across the menstrual cycle affect cognition and symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in young adult female patients aged 18-25. The innovative, longitudinal study will evaluate how menstrual cycle phase and hormonal fluctuations impact neural circuitry involved in response inhibition and working memory, and how these neurofunctional changes predict short-term longitudinal variation in ADHD symptoms and medication response. The project will be conducted by the University of Kentucky Research Foundation and includes a $320,000 sub-award to The Ohio State University to provide expertise on study design, participant recruitment, neuroimaging data collection and analysis. The long-term goal is to inform personalized, sex-specific assessment and treatment of ADHD in females by identifying optimal windows for medication titration or hormone stabilization across the menstrual/reproductive cycle.
Generated 4/1/25, 5:21 AM