This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,185,966 to the University of Mississippi Medical Center (UMMC) to investigate the relationship between short sleep duration and methamphetamine intake, as well as the role of orexin mechanisms in this phenomenon. The research strategy consists of three specific aims: 1) evaluating the hypothesis that dysregulation of orexin processes...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the role of orexin (hypocretin) signaling in the ventral tegmental area as a potential common mechanism underlying sleep disturbances and drug demand during cocaine abstinence. The total funding amount is $1,118,601.00 over the project period from July 15, 2024 to May 31, 2029. The key objectives of this research are to:...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $571,675.00 to Florida Atlantic University (FAU) to conduct a forward genetic screen to identify novel genes involved in the action of the psychostimulant drug amphetamine (AMPH). The goal is to elucidate the underlying mechanisms by which AMPH generates addiction, using the genetic model organism C. elegans. The researchers will screen a...
This federal Project Grant award of $215,159 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research to understand the relationship between alcohol tolerance, sleep, and the development of alcohol use disorder. The research, to be conducted at the University of California, Merced over the 2-year period from September 2024 to August 2026, aims to map the neural circuits and genetic mechanisms...
This federal Project Grant award of $207,307 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research investigating the relationship between alcohol tolerance and alcohol self-administration in the Drosophila (fruit fly) model organism. The primary objectives are to systematically analyze genes affecting initial alcohol resistance/sensitivity and tolerance, develop a robust assay for...
The National Institute on Drug Abuse (NIDA) awarded a $272,395 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Regents of the University of California, San Francisco (UCSF) to research the role of the epigenetic regulators G9A and GLP in the development of addictive behaviors. The key objectives are to: 1) Identify specific molecular surfaces that enable manipulation of the different G9A/GLP dimers and their chromatin binding activities, and 2) Examine how...
This $445,500 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research at the University of Alabama at Birmingham (UAB) to investigate the effects of chronic cocaine exposure on the nervous system of the nematode Caenorhabditis elegans. The research team will generate comprehensive molecular, behavioral, and neuronal activity atlases to identify genetic regulators underlying drug-induced plasticity...
This federal Project Grant award, with ID R01NS140165, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $529,878 award will fund research at Boston Children's Hospital to study the molecular mechanisms that trigger and sustain lasting changes in dopamine signaling, which underlie motivational disruptions seen in mental illnesses like depression,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $417,861 to the Regents of the University of Minnesota to investigate the neural mechanisms underlying individual differences in reward-based learning strategies and their relationship to addiction-like behaviors. The research will focus on the role of dopamine signaling in the basolateral amygdala in mediating these learning processes and...
This $492,000 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will fund a research project at the University of Chicago to elucidate the genetic and epigenetic factors underlying cocaine addiction. The key objectives of the project are to: 1) conduct high-resolution chromatin accessibility and DNA methylation profiling to delineate cell-type and circuit-specific epigenetic...