This $619,477 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate the impact of electronic cigarette (e-cigarette) exposure, both direct and in-utero, on vascular function and cognitive decline. The research, conducted by the West Virginia University Research Corporation, aims to establish the dose-dependent effects of e-cigarette exposure on vascular dysfunction and...
This $900,000 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) aims to determine the impact of prenatal exposure to copper from electronic nicotine delivery system (ENDS) aerosols on the neonatal pulmonary immune system and associated development of asthmatic responses. The research team at Louisiana State University will leverage in vitro and in vivo models to investigate the role of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to investigate the potential transgenerational impacts of e-cigarette use on abdominal aortic aneurysm (AAA) risk. The $355,000 award to the Palo Alto Veterans Institute for Research (PAVIR) will support a four-year study to examine how exposure to nicotine from e-cigarettes and...
This federal Project Grant award for $720,855 was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program. The award supports the "ENDS Aerosol Particle Deposition, In Utero Exposures and Children's Respiratory Health Effects (ENDURE)" consortium to investigate the effects of in utero exposure to electronic nicotine delivery system (ENDS) aerosols on offspring respiratory health. Key products and services under...
DISSOLVED PHASE HYPERPOLARIZED XENON-129 MRI: A NOVEL BIOMARKER TO QUANTIFY PULMONARY PATHOLOGY IN YOUNG HEALTHY E-CIGARETTE USERS - PROJECT SUMMARY OVER THE PAST TEN YEARS, ELECTRONIC CIGARETTES (E-CIGARETTES) HAVE BEEN COMMERCIALIZED AS A "LESS HARMFUL" ALTERNATIVE TO TRADITIONAL CIGARETTES. PRECLINICAL MODELS SHOW THAT E-CIGARETTES CAUSE PULMONARY EPITHELIAL, ENDOTHELIAL, AND VASCULAR DYSFUNCTION SIMILAR TO HUMAN COPD. E-CIGARETTE USE HAS ALSO BEEN ASSOCIATED WITH CARDIAC AND PULMONARY...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,315,596.00 to the Hennepin Healthcare Research Institute (HHRI) to investigate the effects of maternal exposure to electronic nicotine delivery system (ENDS) aerosols during pregnancy on addiction-related behaviors and neurobiological outcomes in offspring. The study aims to use animal models to understand how maternal ENDS use impacts...
The National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) awarded a $247,433 Project Grant to the University of Nebraska Medical Center (UNMC) for the "Parents Helping Parents for Youth Vaping Cessation (PHP-VX)" program. The goal of this feasibility study is to develop and test a parent-facilitated youth vaping cessation intervention, which will include online training sessions and weekly parent-to-parent support. A key sub-award of $34,102 was made to the...
The National Institutes of Health (NIH), through the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077), awarded a $669,321 project grant to the Regents of the University of California at Riverside (UC Riverside). The grant supports a 1-year study to characterize new and emerging ingredients, acids, toxicants, and indicators of non-tobacco nicotine in electronic cigarette (e-cigarette) products. The research will involve: Analyzing 600 commercial...
This is a Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanisms by which vaping the vitamin E acetate compound (A-T-acetate) generates a novel toxic compound that induces fever and lung inflammation. The total funding for this multi-year project is $230,618, with an award date of January 8, 2025 and an ultimate completion date of December 31, 2026. The...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $265,239 to the University of North Carolina at Chapel Hill to evaluate the chemical composition and toxicity of vaping products containing alternative nicotine formulations, such as 6-methyl nicotine. The key objectives are to: 1) Analyze the chemical composition and metabolism of 6-methyl nicotine and nicotinamide vaping products before...