Project Grant R56ES034792

Award Date 8/15/23
Completion Date 7/31/24
Dollars Obligated $669K
Funding Federal Agency
Office of the Director
Federal Grant Program
93.077
Assistance Type
Project Grant
Place of Performance
Riverside, CA 92521, USA
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The National Institutes of Health (NIH), through the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077), awarded a $669,321 project grant to the Regents of the University of California at Riverside (UC Riverside). The grant supports a 1-year study to characterize new and emerging ingredients, acids, toxicants, and indicators of non-tobacco nicotine in electronic cigarette (e-cigarette) products. The research will involve:

  1. Analyzing 600 commercial e-cigarette products to identify flavor chemicals, nicotine forms, and acid additives, with the data organized in the UC Riverside/Penn State University e-cigarette database.
  2. Investigating the potency and biological effects of pure emerging ingredients and worrisome flavor chemical mixtures in human respiratory tissue cultures, without heating.
  3. Repeating the toxicology testing from the second aim with heated aerosol exposures using relevant e-cigarette heating levels and commercial e-liquid products.

The findings will reveal the toxicity implications of new e-cigarette ingredient chemicals and inform risk assessments to identify chemicals of greatest public health concern.

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