This $720,855 federal Project Grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports the "ENDS Aerosol Particle Deposition, In Utero Exposures and Children's Respiratory Health Effects (ENDURE)" research consortium. The project aims to investigate the deposition of electronic nicotine delivery system (ENDS) aerosols in the lungs of pregnant women and assess the resulting effects on respiratory health outcomes in their offspring. Key activities include:
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Quantifying the deposited dose of harmful substances from ENDS aerosols in human airways and estimating associated health risks.
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Evaluating the role of the IL-10 gene in regulating pulmonary function, inflammation, and the lung epigenome in in utero ENDS-exposed mouse offspring.
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Determining the impact of parental ENDS use on infant recurrent wheeze, asthma-like symptoms, and buccal DNA methylation in a cohort of children in Indiana.
The project runs from Mar 2025 through Feb 2028 and is being conducted by the Trustees of Indiana University, a major public research institution with expertise in biomedical sciences, public health, and environmental sciences.
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