This $499,761 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by the Albert Einstein College of Medicine in Bronx, NY. The award aims to define the connectivity between hypothalamic melanocortin peptide-expressing neurons and melanocortin 4 receptor (MC4R)-expressing neurons in the medial prefrontal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $659,199 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Pittsburgh. The grant, awarded on February 25, 2025, supports research to investigate a novel pathway by which hepatocyte-derived growth differentiation factor 15 (GDF15) can improve obesity-associated insulin resistance independent of changes in body weight and the GDF15...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,500.00 to the University of Washington to investigate the links between hypothalamic microglia activation and perineuronal net (PNN) loss in the arcuate nucleus, and how these changes contribute to the pathogenesis of diet-induced obesity and glucose regulation. The...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $136,449 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of California, Berkeley. The award, which runs from December 1, 2024 to November 30, 2026, will fund research to optimize the use of CRISPR-mediated gene downregulation to rapidly test whether genes linked to human obesity are required for the function of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will provide $642,343 to American University to conduct research on the effects of federal funding for obesity prevention programs on weight-related health behaviors, obesity prevalence, and obesity-related chronic conditions. The project will leverage variation in which counties and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to evaluate the therapeutic potential of a new orally active small molecule in obesity-linked diabetic models. The $418,560 award, effective September 1, 2024 through April 30, 2025, supports research to: 1) analyze the pharmacokinetic profiles of a new small molecule, 2) investigate the efficacy and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $504,705 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Appalachian State University in North Carolina. The 3-year grant, awarded on April 5, 2025, will fund research to examine the estrogenic regulation of orexin neurons and reveal subpopulations. Orexin neurons in the hypothalamus are critical regulators of sleep, arousal, energy balance, stress,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research to understand the neural populations in the nucleus of the solitary tract (NTS) that mediate the suppression of food intake. The $502,233 award to the Regents of the University of Michigan aims to define the NTS neuron populations that control food intake and body weight, and distinguish...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $695,295.00 to study the developmental trajectories of reinforcer pathology and childhood obesity. The project will assess how the reinforcing value of food and physical activity, as well as delay discounting, change throughout childhood and adolescence, and how these...
The federal Project Grant award R01DK141559 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $1,280,753 award, effective December 1, 2024 through November 30, 2029, supports research to investigate the role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic disease. The research aims to determine how...