The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $499,761 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Albert Einstein College of Medicine, a private non-profit educational institution in the Bronx, New York.
The grant supports research to define the connectivity between hypothalamic melanocortin peptide-expressing neurons and melanocortin 4 receptor-expressing neurons in the medial prefrontal cortex (mPFC) subregions. The project aims to determine the necessity of the melanocortin 4 receptor in mPFC subregions for obesity-related physiology, food intake, and cognitive behavior. The research will demonstrate the functional effects of this putative circuit on feeding, metabolism, and cognitive behavior in male and female mice. The results are expected to identify critical targets linking feeding behavior, cognitive function, and obesity, potentially leading to new avenues for novel treatment.
Generated 3/4/25, 8:13 AM