The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $616,256 project grant (CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research) to Cleveland State University to develop and validate a "regenerative rehabilitation" therapy for volumetric muscle loss (VML) injuries. The project aims to create an "intelligent biorobot" - a piezoelectric construct that can introduce myoblasts and provide electrical stimulation to expedite...
This $420,883 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve muscle regeneration and restore function following serious traumatic injuries. The University of Missouri System, the prime recipient, will leverage its expertise in microvascular imaging, muscle biology, and biomaterials to investigate the role of fibroadipogenic...
This Project Grant award of $473,377 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research, supports research to modulate the stem cell niche and improve skeletal muscle regeneration. The key objectives are to: Interrogate how muscle cells arise and develop functional characteristics from human pluripotent stem cells (hPSCs) through analysis of myogenic commitment factors and inhibition of...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $557,357 to the University of Wisconsin System to study the role of HOX-expressing interstitial cells in skeletal muscle growth, homeostasis, and regeneration. The research aims to interrogate the potential of these cells to contribute to muscle development and repair, with the goal...
This federal Project Grant award of $820,142, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research investigating the impact of early-life physical inactivity on muscle quality and function in adulthood. The key objectives of this research project are to: 1) examine the effects of varying levels of early-life physical inactivity in mice on muscle...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is for a study titled "Targeting Mitochondrial Permeability Transition to Attenuate Adverse Muscle Impact in Sepsis". The $193,188 award, effective from Sep 1, 2024 to Aug 31, 2026, will investigate the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $540,021 to the University of North Florida to conduct research on the functional role of the DUSP4 protein in regulating skeletal muscle size and strength. The key objectives are to: Determine if DUSP4 expression is necessary and sufficient to induce muscle atrophy using in vivo electroporation to knockdown or overexpress DUSP4...
This federal Project Grant award of $458,907 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the potential of the gut microbiome to treat skeletal muscle atrophy. The award, effective February 1, 2025 through January 31, 2030, aims to determine if cecal microbial transplant from exercise-trained mice can attenuate muscle atrophy, and...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $354,200 to Virginia Polytechnic Institute & State University (Virginia Tech) to investigate the role of endothelial-derived reactive oxygen species (ROS) in regulating skeletal muscle metabolic responses to exercise. The research aims to elucidate the signaling mechanisms...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $177,872 to the University of Houston System to study the interaction between human induced pluripotent stem cell (hiPSC)-derived endothelial cells and skeletal muscle progenitor cells, both in vitro and in vivo. The research aims to elucidate the underlying mechanisms governing the...