This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to investigate a novel subset of Hox-expressing interstitial cells and their role in skeletal muscle growth, homeostasis, and regeneration. The $557,357 award to the University of Wisconsin - Madison will be used to interrogate the lineage potential and functional contributions of these understudied muscle progenitor cells through in vivo studies, genetic manipulations, and in vitro/ex vivo analyses. The research aims to fill critical gaps in the understanding of muscle biology and explore new regenerative approaches for addressing muscle loss in conditions like muscular dystrophy. This award is part of NIAMS's broader efforts to support multidisciplinary, translational research targeting the causes, treatment, and prevention of musculoskeletal disorders through the Arthritis, Musculoskeletal and Skin Diseases Research program.
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