This Project Grant award of $212,095.00 from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to investigate changes in cholinergic modulation during aging and how they contribute to alterations in hippocampal network activity that can lead to age-related memory loss and cognitive decline, a key risk factor for Alzheimer's disease. The primary objectives are to: 1) acquire high-quality experimental data on neural firing patterns and cholinergic modulation dynamics in...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $503,887.30 is aimed at elucidating the role of the supramammillary nucleus (SUM) in modulating hippocampal theta oscillations and their relationship to age-related memory deficits. The award will support research to dissect the SUM-hippocampal circuits, probe their physiological functions in hippocampal theta oscillations, and elucidate how aging-related changes in the SUM...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is providing $436,775 to Brandeis University to investigate how individual differences in the brain's dopamine system may contribute to resilience against Alzheimer's disease pathology. The key objectives of this 2-year research project are to: Determine if the DRD2 T/T genotype, associated with higher dopamine D2 receptor availability, confers greater cortical thickness despite the presence of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $749,108 to the University of California, Irvine to conduct research on how memory failures impact decision-making in aging populations, including those with Alzheimer's disease and related dementias. The 5-year project, which started on May 15, 2025, will use a combination of computational modeling, neuroimaging, and advanced diffusion imaging to examine how declines in item, context,...
This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, supports a $423,500 research project at The Leland Stanford Junior University. The 2-year project, running from May 1, 2025 to April 30, 2027, will examine the relationships between behavioral rhythms of attention and episodic memory, and how these processes are altered in aging independent of Alzheimer's disease. The research will utilize concurrent behavioral, electrophysiological,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $157,568.00 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to study the joint effects of dopamine and tau on cognition in aging. The project will leverage multimodal MRI/PET neuroimaging to examine how increased dopamine levels and tau pathology interact to impact reward memory and hippocampal neural activity in older adult participants. Specific...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...