Project Grant R21AG087912

Award Date 8/15/24
Completion Date 6/30/26
Dollars Obligated $429K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Fairfax, VA, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $385,612 aims to integrate experimental and computational models to study prefrontal microcircuit changes during healthy aging and Alzheimer's disease progression. The research team at the University of Wyoming will use in vivo calcium imaging, computational simulation modeling, and neural decoding to directly visualize and predict microcircuit changes in the prefrontal cortex. A sub-award of an...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $636,342 to Trustees of Boston University's Boston University Medical Campus to conduct multiscale modeling and empirical studies of normal and pathological brain aging. The research aims to elucidate the relationships between myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the dorsolateral prefrontal cortex, and how these changes contribute to age- and Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $749,108 to the University of California, Irvine to conduct research on how memory failures lead to decision-making failures in older adults. The project aims to understand the influence of different types of memory (item, context, statistical learning) on decision-making, using computational frameworks, neuroimaging, and advanced diffusion imaging. It will assess how memory specificity...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $423,500 to The Leland Stanford Junior University to conduct research on the neurobiological mechanisms underlying attention and memory processes, and how they are altered in human aging. The 2-year project will examine behavioral, electrophysiological, and pupillometry-based rhythms of feature-based attention and episodic memory encoding in a well-powered sample of 150 young and cognitively...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $753,794.60 to the Research Foundation For Mental Hygiene, Inc. (RFMH) at its Nathan S Kline Institute Division to elucidate the role of the supramammillary nucleus (SUM) as a key modulator of hippocampal theta oscillations and explore its potential as a therapeutic target for age-related memory deficits. The funded project aims to: 1) dissect the SUM-hippocampal circuits and their physiological...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,500.00 to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The research aims to test the hypothesis that changes in PNN and parvalbumin-positive neurons coincide with delirium-like cognitive impairment in aged mice subjected to anesthesia, surgery, and intensive care unit (ICU)-like conditions. The project will also examine whether...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $817,357 to the J. David Gladstone Institutes to develop advanced machine learning approaches for comprehensive behavioral and brain signal analysis in humanized Alzheimer's disease mouse models. The key products and services to be delivered include: Validating a machine learning platform called Variational Animal Motion Embedding (VAME) for high-resolution...

This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $428,835 to George Mason University to investigate changes in the temporal dynamics of cholinergic modulation during aging and how these changes contribute to alterations of network activity in the hippocampal area CA3 that can result in age-related memory loss and cognitive decline.

The key products and services to be delivered under this award include:

  • Acquiring a high-quality experimental dataset on neural firing in area CA3 and temporal dynamics of cholinergic modulation using parallel recordings of multiple single units in CA3 and fiber photometry recordings in freely behaving mice performing a hippocampus-dependent spatial memory task.
  • Developing a biologically realistic, full-scale spiking neural network model of the hippocampal CA3 circuit to investigate encoding and retrieval dynamics during behavioral activities requiring memory acquisition or recall.
  • Conducting experiments in aged mice and quantitative analysis of computational model outputs to generate testable hypotheses on the functional role of neuron types for network patterns associated with spatial memory and pattern completion, and the effects of cholinergic modulation on neural activity underlying memory processes and their changes during aging.
  • Exploring the quantitative effects of muscarinic and nicotinic receptors on individual neuron types within CA3 and mechanisms like synaptic modification and structural plasticity that may underlie changes in memory encoding and retrieval observed in aged mice.
  • Testing novel, specific hypotheses of memory impairment through closed-loop optogenetic manipulations of temporal dynamics in cholinergic modulation in freely behaving young and aged mice.

Generated 8/5/25, 5:49 AM