Project Grant R03TR006459
- Federal Grant Award Summary Yale University received a $802,715 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) effective March 1, 2026, with a completion date of January 31, 2030. The project investigates pathogen-induced biliary inflammation in the pathogenesis of sclerosing cholangiopathies, particularly primary sclerosing cholangitis (PSC), a chronic...
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Project Grant Award Summary Yale University received a $819,674 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded May 15, 2026, with completion targeted for April 30, 2031. The grant funds development and application of advanced computational methods to identify autoreactive B cells in myasthenia gravis (MG), an antibody-mediated autoimmune disease. The research...
- Federal Grant Award Summary Yale University received a $3.23 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2029. The award supports investigator-initiated biomedical research focused on understanding the role of neutrophils in the pathogenesis of cholangiopathies—a group of bile duct diseases...
- Federal Grant Award Summary Yale University received a $1.54 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for May 31, 2029. The project, "Endothelial Protocadherins in Vascular Development and Disease," delivers mechanistic research investigating gamma protocadherins (PCDHG) as regulators of vascular stability and inflammation. The...
- Federal Project Grant Award Summary Yale University received a $1.5 million Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The award funds the development of a systems immunopeptidomics framework designed to investigate the role of self-peptides in regulating T cell immune responses. The research integrates next-generation mass spectrometry,...
- Federal Project Grant Award Summary Yale University received a $2,685,326 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded July 7, 2025, with a completion date of June 30, 2029. The award supports biomedical research investigating the regulation of neutrophil plasticity, heterogeneity, and functional ambivalency by Wnt5 proteins in the context of colitis. The research focuses on...
- Federal Grant Award Summary Yale University received a $373,090 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with a completion date of July 31, 2026. The award supports development of Modular Degraders of Extracellular Proteins (MODES), a novel therapeutic approach designed to remove pathogenic extracellular proteins from circulation. The research program...
- Federal Project Grant Award Summary Yale University received an $818,300 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2026, with completion targeted for July 31, 2031. The award funds the development of Modular Degraders of Extracellular Proteins (MODES)—bifunctional small-molecule therapeutics designed to selectively remove extracellular proteins, particularly...
- Federal Grant Award Summary Yale University received a $251,938 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 9, 2026, with completion targeted for May 31, 2028. The award supports research investigating heterogeneity in autoimmune myasthenia gravis (MG), specifically examining the underexplored role of immunoglobulin M (IgM) autoantibodies in disease pathogenesis. The...
Yale University received a $168,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective August 1, 2026 through July 31, 2027. This high-risk, high-reward research initiative investigates the role of P2RY8, a G-protein-coupled receptor, in B cell-endothelial cell crosstalk within the context of primary biliary cholangitis (PBC), a chronic autoimmune liver disease. The project will deliver two primary research products: (1) characterization of how P2RY8 signaling reprograms liver lymphatic endothelial cell (LYEC) phenotype, and (2) analysis of how LYEC P2RY8 activity influences B cell activation and anti-mitochondrial antibody (AMA) production in PBC pathogenesis. The research is designed to establish a novel conceptual framework for understanding autoimmune cholangiopathies by uncovering previously unexplored LYEC-B cell communication mechanisms and will generate foundational knowledge to support future therapeutic development targeting P2RY8. The work addresses a significant gap in understanding immune cell regulation within the liver microenvironment and aims to identify new treatment targets for PBC, a disease characterized by immune system attacks on bile duct cells leading to cholestasis, fibrosis, and eventual liver failure.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $168.0k | 7/14/26 |