Project Grant DP2CA311216
Award Date 9/1/25
Completion Date 8/31/28
Dollars Obligated $1.5M
Funding Federal Agency
Awarding Federal Agency
Awardee
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
Similar Awards
- This federal Project Grant award of $672,371.00 from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research at Yale University to develop ultra-sensitive mass spectrometry-based immunopeptidomics using digital microfluidics. The project aims to improve the identification of tumor-specific antigens (TSAs) to support the development of effective cancer immunotherapies. The award has a performance period from September 1, 2025...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This $858,186 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project titled "Decoding T Cell Clonotypes, Biology and Predictive Biomarkers Associated with Immune Checkpoint Myocarditis." The project aims to investigate the mechanisms underlying immune-related myocarditis, a potentially fatal adverse event associated with immune checkpoint inhibitor cancer therapies. Using...
- This Project Grant award of $404,032 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a machine learning-powered platform for the discovery of peptide ligands for peptide-drug conjugates (PDCs). The key objective is to create a next-generation peptide discovery system capable of identifying PDC leads within 3 months. The platform will utilize a peptide array designed for enhanced protease...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- The federal Project Grant award of $1,602,000.00 from the National Institute of Environmental Health Sciences, under the Medical Library Assistance program (CFDA 93.879), will support the development of computational methods for analyzing multiplex immunofluorescence (MIF) imaging data to study the tumor microenvironment. The project aims to leverage a unique MIF dataset from over 2,000 cancer patients across 20 tumor types to develop innovative computational strategies, including spatial...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $1,400,954.00 to The Leland Stanford Junior University to conduct research on combinatorial engineering of multicellular synthetic immunotherapy systems. The research program aims to: (1) co-optimize chimeric antigen receptors (CARs) and synthetic cytokine receptors (SCRs) to enhance anti-tumor immune cell function; (2) co-engineer T cells,...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,135 to develop a new magnetics-based method for rapidly mapping the mechanical properties of tissues. The goal is to address technical limitations of current scanning probe methods used to study the tumor microenvironment and its impact on T cell function in solid tumors. The award will fund the development and...
- This Project Grant award of $124,134 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the mechanisms of pathogenesis and treatment response in immune checkpoint inhibitor-induced colitis. The research aims to define the role of specific T cell subsets recruited from circulation in promoting inflammation and mediating therapeutic response in this condition, which can occur in up to 40% of cancer patients receiving immune checkpoint...
- The New York University (NYU) School of Medicine was awarded a $1,525,500 Project Grant by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant funding, which runs from September 1, 2024 to August 31, 2027, supports the development of new technologies to address two major bottlenecks in the chimeric antigen receptor (CAR) T cell therapy development process: identifying tumor-specific antigens and engineering...