Project Grant R01AI194181
- Federal Grant Award Summary Yale University received a $373,090 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 25, 2025, with a completion date of July 31, 2026. The award supports development of Modular Degraders of Extracellular Proteins (MODES), a novel therapeutic approach designed to remove pathogenic extracellular proteins from circulation. The research program...
- Federal Project Grant Summary Yale University received a $751,919 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 17, 2026, with completion targeted for May 30, 2031. The grant supports fundamental research into the transcriptional control of Activation Induced Deaminase (AID) function and its role in somatic hypermutation (SHM) and class switch recombination...
- Federal Grant Award Summary Yale University received a $251,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 2, 2025, with a completion date of August 31, 2027. The grant supports research to identify new antigens in seronegative myasthenia gravis (SNMG), an autoimmune neuromuscular disorder characterized by the absence of detectable autoantibodies to known...
- Federal Grant Award Summary Yale University received a $819,674 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective May 15, 2026, with completion scheduled for April 30, 2031. The award supports the development of mechanistically informed deep learning computational models to identify autoreactive B cells in myasthenia gravis (MG) patients, particularly those who are...
- Federal Project Grant Award Summary Yale University received a $105,402 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 27, 2026, with completion targeted for April 15, 2029. The research project, "Mechanisms of Resilience to Cytokinopathy Flares," focuses on elucidating the molecular machinery that restores immune homeostasis following inflammatory...
- Federal Project Grant Award Summary Yale University received a $462,052 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 19, 2026, with a completion date of January 31, 2028. The award supports research investigating the role of Erythroblast Transformation Specific 2 (ETS2), a transcription factor, in mediating monocyte and macrophage activation in systemic lupus...
- Federal Project Grant Award Summary Yale University received a $2,685,326 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded July 7, 2025, with a completion date of June 30, 2029. The award supports biomedical research investigating the regulation of neutrophil plasticity, heterogeneity, and functional ambivalency by Wnt5 proteins in the context of colitis. The research focuses on...
- Federal Grant Award Summary Yale University received a $3.13 million Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 25, 2025, with a completion date of June 30, 2029. The grant funds investigator-initiated biomedical research focused on elucidating the mechanisms of lymphoid-specific beta-catenin protein degradation in B-lymphoid cells. The research will characterize how B-cells...
- Federal Project Grant Award Summary Yale University received a $251,938 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 12, 2026, with completion scheduled for May 31, 2028. The research focuses on discovering and validating cell-intrinsic immunologic adjuvants to enhance next-generation self-amplifying RNA (saRNA) vaccines against infectious diseases. The project addresses...
- Federal Grant Award Summary Yale University received a $453,629 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 8, 2025, with completion targeted for June 30, 2027. The grant supports development and application of PHAGE-SEQ, a high-throughput technology combining phage display of nanobodies (VHH recognition domains derived from camelid heavy chain-only immunoglobulins)...
Yale University received an $818,300 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 1, 2026, with completion targeted for July 31, 2031. The award funds development of Modular Degraders of Extracellular Proteins (MODES)—bifunctional small-molecule therapeutics designed to selectively degrade extracellular proteins, particularly autoantibodies, from circulation. The research deliverables include: (1) improved MODES compounds incorporating novel asialoglycoprotein receptor (ASGPR) ligands with enhanced affinity and oral bioavailability, developed through computer-assisted molecular modeling and medicinal chemistry; (2) establishment of a high-throughput assay platform and rigorous mathematical framework for evaluating MODES candidates to accelerate development timelines; and (3) preclinical validation of MODES efficacy in an autoantibody-driven animal model of autoimmune disease. The technology platform creates ternary complexes between target proteins, bifunctional molecules, and ASGPR on hepatocyte surfaces, enabling cellular internalization and lysosomal degradation of pathogenic proteins. This foundational research is intended to enable future clinical development of MODES for treating antibody-driven autoimmune disorders and heart failure. The project represents basic translational research typical of NIAID's portfolio, which prioritizes innovative approaches to infectious and immunologic disease mechanisms.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $818.3k | 7/1/26 |