This $178,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, supports research to better understand the localization and function of the SLC24A5 gene and its role in skin pigmentation. The grantee, The Children's Hospital of Philadelphia (CHOP), will generate a panel of mouse melanocyte cell lines to investigate the subcellular localization of the NCKX5 protein encoded by SLC24A5, and assess the impact of SLC24A5 mutations on melanosome protein levels, trafficking, and pH. This research aims to advance the basic understanding of pigmentation and inform strategies for treating oculocutaneous albinism and mitigating UV radiation damage in individuals with light skin-associated SLC24A5 alleles. The award period is from August 1, 2025 to July 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $178.0k | 7/18/25 |