This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $693,422 to the University of Colorado-Denver from September 1, 2024 to August 31, 2029. The funding will support multidisciplinary research to pursue a fundamental mechanistic understanding of essential membrane transporters, which are critical for cellular function but generally understudied compared to other membrane proteins. The...
This Project Grant award of $534,160 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports advanced research on the molecular mechanisms underlying intracellular ion transport and genome maintenance. The award to the Sloan-Kettering Institute for Cancer Research in New York will fund a 5-year research program focused on four key areas: Elucidating the mechanisms by which ion transport proteins, such as TMEM175,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,538,932.00 to the University of California, Irvine (UCI) over a 5-year period from September 2024 to June 2029. The funding supports research to elucidate the molecular mechanisms underlying the regulation of Protein Phosphatase 2A (PP2A) family phosphatases, including PP2A, PP4, and PP6, in response to environmental signals. The...
This federal Project Grant award of $393,149 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Brandeis University to study the regulation of PPM family serine/threonine phosphatases. The overarching goal is to address two key gaps in knowledge about reversible protein phosphorylation: how phosphatases are regulated and targeted to specific substrate phosphorylation sites. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
This Project Grant award of $179,736.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the post-translational regulation of norad-induced pumilio phase separation. The project aims to investigate how phosphorylation of the RNA-binding protein pumilio1 (PUM1) dynamically regulates the formation and dispersal of biomolecular condensates, known as norad-pumilio (NP) bodies, during the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will provide $377,320 to the University of Washington to conduct research on the structure and regulation of the enzyme phosphofructokinase (PFK), which is essential for glucose metabolism. The research will use cryo-electron microscopy, mutagenesis, in vitro kinetic assays, biophysical assays, and cell-based assays to better define the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $346,677 to the University of Delaware to investigate the connection between arginine phosphorylation and mycobacterial CLP proteases. The research aims to expand understanding of the roles of phosphoarginine in mycobacteria, elucidate the mechanisms of how phosphoarginine-bearing proteins interact with CLP proteases, and determine...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $364,324 to the Regents of the University of Michigan to conduct research on sulfide-regulated copper metabolism. The project aims to characterize how hydrogen sulfide (H2S), a signaling molecule, impacts copper metabolism and the activity of the copper-containing Complex IV in the electron transport chain, particularly in...
This $1,259,550 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project at the University of Washington to study the role of protein phosphorylation in regulating the cellular proteome. The research aims to: 1) identify phosphorylation sites relevant to protein function at a proteomic scale, 2) examine how phosphorylation regulates multi-level proteome organization,...