Project Grant K99HG013662
Award Date
7/1/25
Completion Date
6/30/27
Dollars Obligated
$131K
Federal Agency
National Human Genome Research Institute
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $993,446 Project Grant to the Sloan-Kettering Institute for Cancer Research. The 5-year grant, effective May 1, 2025, will support the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical gene programs and genomic...
This federal Project Grant award of $126,830 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to develop a somatic mutation-resolved lineage tracing system. The project aims to reconstruct single-cell genealogical trees and detect associated somatic mutations and epigenetic alterations. This will enable investigations into the impact of genomic modifications on the evolutionary dynamics of hematopoietic stem cells, including during...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), awarded a $249,000 Project Grant (R00HG012956) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for a project titled "Multi-Omic Dissection of Clonal Hematopoiesis-Associated Diseases." The project aims to develop statistical and machine learning methods to analyze multi-omics data and uncover the molecular mechanisms...
This $400,000 Project Grant award from the National Human Genome Research Institute (NHGRI) under CFDA 93.172 "Human Genome Research" will support a research program at Brigham & Women's Hospital to develop advanced computational methods for accurately identifying and genotyping structural variants within large genetic biobank datasets. The key objectives of the work are to: 1) create haplotype-informed algorithms to improve detection sensitivity and genotyping accuracy for...
The National Human Genome Research Institute (NHGRI) awarded a $1,559,381 Project Grant (CFDA 93.172 - Human Genome Research) to St. Jude Children's Research Hospital Inc. on April 1, 2025. The grant will fund a 4-year research project to decipher the underlying structure of the glucocorticoid gene regulatory network and investigate how genetic alterations to glucocorticoid response cis-regulatory elements impact gene expression and contribute to glucocorticoid drug resistance in B-cell acute...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $1,341,011 Project Grant to the University of Pittsburgh to develop a novel computational framework that integrates deep learning and causal discovery algorithms. The goal is to unveil individualized cell-cell communication networks underlying tissue environment heterogeneity across normal and disease conditions. The framework will leverage single-cell...
The National Human Genome Research Institute (NHGRI) awarded a $470,250 Project Grant (CFDA 93.172 - Human Genome Research) to Children's Hospital Los Angeles (CHLA) to explore the perspectives of diverse parents on issues related to pediatric genome testing, research, and data management. The award will fund a qualitative pilot study utilizing focus groups, interviews, and a survey to: (1) examine attitudes towards genome sequencing for clinical testing and research with a focus on...
The National Human Genome Research Institute (NHGRI), under the 93.172 Human Genome Research federal grant program, awarded a $3,377,867 Project Grant to Survey Genomics, Inc. on September 19, 2024. The grant supports the development and commercialization of the CytopeDrop platform, an innovative approach for spatially-resolved single-cell multiomics analysis. CytopeDrop enables researchers to simultaneously obtain mRNA abundances, protein abundances, and cell locations, providing crucial...
The National Human Genome Research Institute (NHGRI) awarded a $1,711,422 Project Grant (CFDA 93.172 - Human Genome Research) to the New York Genome Center, Inc. (NYGC) on September 23, 2024. The goal of this project is to develop a suite of privacy-preserving tools for transcriptomic data analysis, including methods for quantifying bulk and single-cell gene expression, as well as performing expression quantitative trait locus (eQTL) mapping on encrypted genotypes. This will enable large-scale...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to integrate genetic and socio-environmental factors to predict disease progression. The $138,499 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) aims to develop statistical models that leverage genetic, longitudinal healthcare, and socio-environmental data to enhance precision medicine for 16 exemplar disease...