Project Grant R03MH139980
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $443,575 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how maternal immune activation alters dopamine circuit function and development. The project examines the structural and functional impact of in utero immune activation on the striosome-dendron bouquet, a striatal circuit that directly controls dopamine neurons in the substantia nigra pars compacta. Aim 1...
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
- The National Institute of Mental Health awarded Yale University $711,168 under Mental Health Research Grants (CFDA 93.242) on September 1, 2026, to identify circuit mechanisms by which insular cortex immune-responsive neurons alter behavior during peripheral inflammation. The project uses mouse models of type 2 and type 3 inflammation combined with single-cell transcriptomics, electrophysiology, and chemogenetics to determine whether insular cortex immune-responsive neurons are heterogeneous and...
- The National Institute of Mental Health awarded Rosalind Franklin University of Medicine & Science $465,301 on July 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how social deprivation during adolescence impairs basomedial amygdala development and compromises social behavior. The research examines the role of the basomedial amygdala in regulating social engagement across developmental stages, with specific focus on how atypical social...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $735,182 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate how social interactions promote recovery from viral infections through interleukin-10 (IL-10)–mediated mechanisms. The research uses murine models to explore the neural-immune pathways linking social touch, oxytocin, and IL-10 in recovery from virally induced sickness behaviors. The project will determine...
- The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...
- The National Institute of Mental Health awarded $466,175 to Massachusetts General Hospital on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neuroimmune circuitry implicated in major depressive disorder and treatment-resistant depression. The recipient will conduct multimodal neuroimaging and anatomical research to elucidate circuits connecting limbic regions with the nucleus tractus solitarii in the brainstem, a neural pathway through which inflammatory...
- The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling....
The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior work showed that early life adversity derails development of prefrontal cortex excitatory signaling and that anti-inflammatory treatment can prevent increased NR2A expression, suggesting immune signaling plays a role in synapse refinement. The project will test a direct mechanistic link between microglial activity and NR2A receptor development in this context, examining whether early life adversity accelerates microglial maturation and whether microglial state shifts drive heightened NR2A expression that contributes to later-life neuropsychiatric vulnerability. The work is classified as a Project Grant, an assistance type supporting specified research efforts. Performance occurs in Boston, Massachusetts, with a period of performance from September 1, 2026, through August 31, 2028. The award is part of NIMH's mission to transform understanding and treatment of mental illness through basic and clinical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $157.5k | 9/1/26 |