Project Grant R21MH141295
- The National Institute of Mental Health awarded Massachusetts Institute of Technology (MIT) $803,849 on June 3, 2026, as a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to conduct brain-wide analysis of input/output relationships in the reward system. MIT will use functional magnetic resonance imaging (fMRI) techniques to study integrated input/output relationships between brain regions involved in reward-related tasks. The research centers on a novel genetically...
- The National Institute of Mental Health awarded The Research Foundation For The State University Of New York $802,543 on June 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to dissect the role of astrocytes in mediating adverse outcomes of maternal immune activation. The project grant funds research examining how prenatal infections triggering maternal immune activation contribute to neurodevelopmental disorders including schizophrenia, autism spectrum disorder, and...
- The National Institute of Mental Health awarded President and Fellows of Harvard College $674,028 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the determinants and function of tonic dopamine signaling in the striatum. The research develops and applies real-time measurement methods to distinguish tonic dopamine (slowly changing baseline levels) from phasic dopamine (rapid transient signals) in mice across multiple behavioral contexts. The project...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $127,224 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate neural mechanisms governing sensory-driven decision making through study of amygdala-striatal pathways. The K99 award (K99MH141244) funds research into how basolateral amygdala neurons projecting to the tail of the striatum instruct the selection of instrumental actions during perceptual decision making. The...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $543,711 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242, Assistance Listing R01MH145508) to investigate endocannabinoid-mediated inhibitory synaptic mechanisms of hippocampal plasticity using all-optical physiology. The research employs simultaneous patterned optogenetic stimulation and genetically targeted voltage imaging to track synaptic plasticity with millisecond and...
- The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling....
- The National Institute of Mental Health awarded $466,175 to Massachusetts General Hospital on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neuroimmune circuitry implicated in major depressive disorder and treatment-resistant depression. The recipient will conduct multimodal neuroimaging and anatomical research to elucidate circuits connecting limbic regions with the nucleus tractus solitarii in the brainstem, a neural pathway through which inflammatory...
- The National Institute of Mental Health awarded Trustees of Boston University $449,625 on July 9, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct basic neuroscience research on behavioral functions of cotransmission in cost/benefit decision-making. The research examines how dopamine release in distinct striatal subregions supports different forms of learning—reward-based versus threat-based—and tests a specialized neural circuit linking the tail of the striatum,...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $805,382 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study social perception and cognition in a marmoset model of Phelan-McDermid Syndrome. The award funds research into neural impairments in social perception and cognition caused by SHANK3 gene mutations, with investigation of whether gene therapy can correct those impairments. MIT will implant electrocorticography...
The National Institute of Mental Health awarded Massachusetts Institute of Technology $443,575 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how maternal immune activation alters dopamine circuit function and development. The project examines the structural and functional impact of in utero immune activation on the striosome-dendron bouquet, a striatal circuit that directly controls dopamine neurons in the substantia nigra pars compacta. Aim 1 determines whether maternal immune activation causes alterations in this striosomal-dopamine circuit. Aim 2 assesses the role of the dopamine-antagonistic nociceptin system in circuit development and function. The research aims to elucidate developmental mechanisms of dopamine circuit disruption and identify potential therapeutic targets for neuropsychiatric outcomes associated with dopamine dysregulation. The award is a project grant with a period of performance from September 1, 2026, through August 31, 2028. Work is performed in Cambridge, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $443.6k | 8/31/26 |